cad a22 4500 569303214 20200215084059.0 cr unu---uuuuu 190726e20190612xx s 000 0 eng 10.5167/uzh-171735 doi 10.1128/JCM.00339-19 doi (ZORA)oai:www.zora.uzh.ch:171735 610 ddc 31189580 pmid periprosthetic joint infections diagnosed with growth in cultures [Elektronische Daten] [Aleš Chrdle, Tomáš Trnka, David Musil, Sandro F Fucentese, Peter Bode, Peter M Keller, Yvonne Achermann] openAccess eu-repo Tularemia caused by is a zoonotic infection of the Northern Hemisphere that mainly affects skin, lymph nodes, bloodstream and lungs. Other manifestations of tularemia are very rare, especially with musculoskeletal involvement. Presenting in 2016, we diagnosed two cases of periprosthetic knee joint infections (PJI) caused by in Europe (one in Switzerland, one in Czech Republic). We only found two other PJI cases in literature, another knee PJI diagnosed 1999 in Ontario, Canada, and one hip PJI in Illinois, USA 2017. Diagnosis was made in all cases by positive microbiological cultures after 3, 4, 7, and 12 days. All were successfully treated, two cases with exchange of the prosthesis, one with debridement and retention, and one with repeated aspiration of the synovial fluid only. Antibiotic treatment was given between 3 weeks and 12 months wither either ciprofloxacin/rifampin or with doxycycline alone or doxycycline in combination with gentamicin.Zoonotic infections should be considered in periprosthetic infections in particular in culture negative PJIs with a positive histology or highly elevated leucocytes in synovial aspiration. Here we recommend to prolong cultivation time up to 14 days, perform specific PCR tests, and/or do epidemiologically appropriate serological tests for zoonotic infections including that for . Institute of Pathology and Molecular Pathology zora Clinic for Infectious Diseases zora Chrdle Aleš joint author Trnka Tomáš joint author Musil David joint author Fucentese Sandro F. joint author Bode Peter joint author Keller Peter M. joint author Achermann Yvonne joint author Journal of Clinical Microbiology 57(8):e00339-19 https://www.zora.uzh.ch/id/eprint/171735/1/Chrdle_journal_of_clinical_microbiology_2019.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/171735/1/Chrdle_journal_of_clinical_microbiology_2019.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Chrdle Aleš joint author ZORA 700 1- Trnka Tomáš joint author ZORA 700 1- Musil David joint author ZORA 700 1- Fucentese Sandro F. joint author ZORA 700 1- Bode Peter joint author ZORA 700 1- Keller Peter M. joint author ZORA 700 1- Achermann Yvonne joint author ZORA 773 0- Journal of Clinical Microbiology 57(8):e00339-19 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article openAccess