nad a22 4500 569303354 20190726063010.0 cr unu---uuuuu 190726e201907 xx s 000 0 eng 10.5167/uzh-171758 doi 10.1016/j.ijom.2019.01.008 doi (ZORA)oai:www.zora.uzh.ch:171758 610 ddc 30738712 pmid The influence of lymph node ratio on survival and disease recurrence in squamous cell carcinoma of the tongue [Elektronische Daten] [L Hingsammer, T Seier, J Ikenberg, P Schumann, D Zweifel, M Rücker, M Bredell, M Lanzer] closedAccess eu-repo This study was performed to report the outcomes of patients with oral squamous cell carcinoma (OSCC) of the tongue over a 10-year period with the aim of testing the hypothesis that the lymph node ratio (LNR) has a significant influence on loco-regional recurrence. The charts of 227 patients with OSCC of the mobile tongue treated at the University Hospital of Zurich from 2003 to 2012 were screened. Following the application of the exclusion criteria (prior chemotherapy, radiotherapy, or surgery, perioperative death, N3 disease, unresectable disease, synchronous second primary, no signed informed consent, and follow-up <3years), prospective data were collected and a retrospective analysis performed for 88 of these patients who were treated with selective neck dissection. During a mean follow-up period of 78 months (standard deviation 37 months), loco-regional recurrence was diagnosed in 25 patients (28%). The overall and disease-specific survival rates for the study population were 72% and 80%, respectively. Perineural invasion was identified as an independent risk factor for decreased disease-specific survival, whereas LNR was not. LNR did not show an influence on disease recurrence. Thus, its prognostic value in patients with tongue cancer remains uncertain and the decision regarding adjuvant therapy should not be made solely on the basis of LNR. Institute of Pathology and Molecular Pathology zora Hingsammer L. joint author Seier T. joint author Ikenberg J. joint author Schumann P. joint author Zweifel D. joint author Rücker M. joint author Bredell M. joint author Lanzer M. joint author International Journal of Oral and Maxillofacial Surgery 48(7):851-856 https://www.zora.uzh.ch/id/eprint/171758/1/Hingsammer_international_journal_of_oral_and_maxillofacial_surgery_2019.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/171758/1/Hingsammer_international_journal_of_oral_and_maxillofacial_surgery_2019.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Hingsammer L. joint author ZORA 700 1- Seier T. joint author ZORA 700 1- Ikenberg J. joint author ZORA 700 1- Schumann P. joint author ZORA 700 1- Zweifel D. joint author ZORA 700 1- Rücker M. joint author ZORA 700 1- Bredell M. joint author ZORA 700 1- Lanzer M. joint author ZORA 773 0- International Journal of Oral and Maxillofacial Surgery 48(7):851-856 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article closedAccess