nad a22 4500 569303451 20190726063010.0 cr unu---uuuuu 190726e20190601xx s 000 0 eng 10.5167/uzh-171768 doi 10.1002/bies.201800191 doi (ZORA)oai:www.zora.uzh.ch:171768 570 ddc 610 ddc 31132173 pmid Rakebrandt Nikolas Infection History Determines Susceptibility to Unrelated Diseases [Elektronische Daten] [Nikolas Rakebrandt, Nicole Joller] openAccess eu-repo Epidemiological data suggest that previous infections can alter an individual's susceptibility to unrelated diseases. Nevertheless, the underlying mechanisms are not completely understood. Substantial research efforts have expanded the classical concept of immune memory to also include long‐lasting changes in innate immunity and antigen‐independent reactivation of adaptive immunity. Collectively, these processes provide possible explanations on how acute infections might induce long‐term changes that also affect immunity to unrelated diseases. Here, we review lasting changes the immune compartment undergoes upon infection and how infection experience alters the responsiveness of immune cells towards universal signals. This heightened state of alert enhances the ability of the immune system to combat even unrelated infections but may also increase susceptibility to autoimmunity. At the same time, infection‐induced changes in the regulatory compartment may dampen subsequent immune responses and promote pathogen persistence. The concepts presented here outline how infection‐induced changes in the immune system may affect human health. Institute of Experimental Immunology zora Infection history, immune regulation zora Joller Nicole joint author BioEssays 41(6):e1800191 https://www.zora.uzh.ch/id/eprint/171768/1/Rakebrandt_-_Bioessays.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora EC/H2020/677200 zora grantAgreement ZORA 856 40 https://www.zora.uzh.ch/id/eprint/171768/1/Rakebrandt_-_Bioessays.pdf text/html WWW-Backlink auf das Repository ZORA 100 1- Rakebrandt Nikolas ZORA 700 1- Joller Nicole joint author ZORA 773 0- BioEssays 41(6):e1800191 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article openAccess