nad a22 4500 569303508 20190726063010.0 cr unu---uuuuu 190726e20190322xx s 000 0 eng 10.5167/uzh-171773 doi 10.1126/science.aat8515 doi (ZORA)oai:www.zora.uzh.ch:171773 610 ddc 30898933 pmid High-fructose corn syrup enhances intestinal tumor growth in mice [Elektronische Daten] [Marcus D Goncalves, Changyuan Lu, Jordan Tutnauer, Travis E Hartman, Seo-Kyoung Hwang, Charles J Murphy, Chantal Pauli, Roxanne Morris, Sam Taylor, Kaitlyn Bosch, Sukjin Yang, Yumei Wang, Justin Van Riper, H Carl Lekaye, Jatin Roper, Young Kim, Qiuying Chen, Steven S Gross, Kyu Y Rhee, Lewis C Cantley, Jihye Yun] closedAccess eu-repo Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed to develop intestinal tumors. The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in the absence of obesity and metabolic syndrome. HFCS increased the concentrations of fructose and glucose in the intestinal lumen and serum, respectively, and the tumors transported both sugars. Within the tumors, fructose was converted to fructose-1-phosphate, leading to activation of glycolysis and increased synthesis of fatty acids that support tumor growth. These mouse studies support the hypothesis that the combination of dietary glucose and fructose, even at a moderate dose, can enhance tumorigenesis. Institute of Pathology and Molecular Pathology zora Goncalves Marcus D. joint author Lu Changyuan joint author Tutnauer Jordan joint author Hartman Travis E. joint author Hwang Seo-Kyoung joint author Murphy Charles J. joint author Pauli Chantal joint author Morris Roxanne joint author Taylor Sam joint author Bosch Kaitlyn joint author Yang Sukjin joint author Wang Yumei joint author Van Riper Justin joint author Lekaye H Carl joint author Roper Jatin joint author Kim Young joint author Chen Qiuying joint author Gross Steven S. joint author Rhee Kyu Y. joint author Cantley Lewis C. joint author Yun Jihye joint author Science 363(6433):1345-1349 https://www.zora.uzh.ch/id/eprint/171773/1/Goncalves_Cancer_2019.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/171773/1/Goncalves_Cancer_2019.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Goncalves Marcus D. joint author ZORA 700 1- Lu Changyuan joint author ZORA 700 1- Tutnauer Jordan joint author ZORA 700 1- Hartman Travis E. joint author ZORA 700 1- Hwang Seo-Kyoung joint author ZORA 700 1- Murphy Charles J. joint author ZORA 700 1- Pauli Chantal joint author ZORA 700 1- Morris Roxanne joint author ZORA 700 1- Taylor Sam joint author ZORA 700 1- Bosch Kaitlyn joint author ZORA 700 1- Yang Sukjin joint author ZORA 700 1- Wang Yumei joint author ZORA 700 1- Van Riper Justin joint author ZORA 700 1- Lekaye H Carl joint author ZORA 700 1- Roper Jatin joint author ZORA 700 1- Kim Young joint author ZORA 700 1- Chen Qiuying joint author ZORA 700 1- Gross Steven S. joint author ZORA 700 1- Rhee Kyu Y. joint author ZORA 700 1- Cantley Lewis C. joint author ZORA 700 1- Yun Jihye joint author ZORA 773 0- Science 363(6433):1345-1349 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article closedAccess