caa a22 4500 569310172 20200410031540.0 cr unu---uuuuu 190727e20190611xx s 000 0 eng 1748-717X 10.1186/s13014-019-1299-8 doi (BORIS)oai:boris.unibe.ch:131419 610 ddc 31186027 pmid Long-term functional outcome after laryngeal cancer treatment [Elektronische Daten] [Lukas Anschütz, Mohamed Shelan, Marco Dematté, Adrian D Schubert, Roland Giger, Olgun Eliçin] publishedVersion openAccess eu-repo BACKGROUND The functional outcome after the treatment of laryngeal cancer is tightly related to the quality of life of affected patients. The aim of this study is to describe the long-term morbidity and functional outcomes associated with the different treatment modalities for laryngeal cancer. METHODS Retrospective chart review of 477 patients undergoing curatively intended treatment for laryngeal cancer at our tertiary referral center from 2001 to 2014: Details on patient and disease characteristics, diagnostics and treatment related functional outcomes were analyzed. RESULTS With a median follow-up of 51 months, the crude rate of functional larynx preservation was 74.6%. Radiotherapy +/- chemotherapy was the dominant treatment modality (n= 359-75.3%), whereas 24.7% (n= 118) underwent primary surgery, with 58.5% (69) receiving adjuvant treatment. The 5-year laryngectomy-free survival was 57% (95% CI, 48-66%) after surgery vs. 69% (95% CI, 64-75%) after chemoradiotherapy (p< 0.01). In stage III-IVB, these rates were 26% (95% CI, 16-39%) vs. 47% (95% CI, 36-59%), respectively (p< 0.01). Aspiration occurred in 7%, tracheostomy was necessary in 19.8% and feeding tube placement in 25.4%. Feeding tube and tracheostomy necessity was higher in the initially surgically treated group. Primary surgery (HR: 1.67, 95% CI: 1.19-2.32; p < 0.01), stage III-IVB (HR: 4.07, 95% CI: 2.97-5.60; p < 0.01) and tumor recurrence (HR: 3.83, 95% CI: 2.79-5.28; p < 0.01) remained as adverse factors for laryngectomy-free survival. CONCLUSIONS Preserving the laryngeal function after cancer treatment is challenging. Advanced tumor stages, primary surgery and recurrence are related to a poor functional outcome. Therefore, the criteria for initial decision-making needs to be further refined. Anschütz Lukas joint author Shelan Mohamed joint author Dematté Marco joint author Schubert Adrian D. joint author Giger Roland joint author Eliçin Olgun joint author Radiation oncology 14(1), p. 101 1748-717X https://boris.unibe.ch/131419/1/document.pdf text/html WWW-Backlink auf das Repository 1 info:eu-repo/semantics/article boris PeerReviewed boris peerstatus BORIS 856 40 https://boris.unibe.ch/131419/1/document.pdf text/html WWW-Backlink auf das Repository BORIS 700 1- Anschütz Lukas joint author BORIS 700 1- Shelan Mohamed joint author BORIS 700 1- Dematté Marco joint author BORIS 700 1- Schubert Adrian D. joint author BORIS 700 1- Giger Roland joint author BORIS 700 1- Eliçin Olgun joint author BORIS 773 0- Radiation oncology 14(1), p. 101 1748-717X BK010053 XK010053 XK010000 BORIS BORIS BORIS info:eu-repo/semantics/article openAccess