nad a22 4500 569329965 20190727060942.0 cr unu---uuuuu 190727e20190503xx s 000 0 eng 10.5167/uzh-172052 doi 10.5152/iao.2019.5758 doi (ZORA)oai:www.zora.uzh.ch:172052 610 ddc Patient Perceptions of Effectiveness in Treatments for Menière's Disease: a National Survey in Italy [Elektronische Daten] [Bryan Ward, Vincent Wettstein, John Golding, Giulia Corallo, Daniele Nuti, Franco Trabalzini, Marco Mandala] openAccess eu-repo OBJECTIVES: The aim of the present study was to investigate current treatment practices and self-reported effectiveness in Ménière's disease. MATERIALS and METHODS: Members of two Italian Ménière's disease support (n=170) with ≥6-month history of Ménière's disease were administered an online survey about recent treatments. Vertigo episode count, work absenteeism, and limitations in family life, social life, work, or travel as included in the Social Life and Work Impact of Dizziness Questionnaire before and after recent treatments were queried. RESULTS: Twenty-four different treatments were reported for Ménière's disease, with dietary modifications (55%), diuretics (47%), and betahistine (41%) being the most common. The majority (71%) received multiple simultaneous treatments. Prior to the most recent treatments, 78%-89% of respondents indicated limitations in family or social life, work, or traveling. After their most recent treatment, respondents reported improvements in mean vertigo episode counts (5.7±7.6 vs. 2.6±4.6, p<0.001), days off work per month (10.1±9.2 vs. 4.2±6.7, p<0.001), and proportions indicating limitations in any functional measure assessed (p<0.05). These findings were consistent regardless of treatment approach (p<0.05 for all). Intratympanic gentamicin provided the greatest reductions in vertigo count, functional limitations, and work absenteeism (p<0.01 for all), as well as the fewest respondents reporting post-treatment functional limitations (16%-37%). CONCLUSION: Despite many treatment approaches targeting different proposed pathophysiology for Ménière's disease in this cross-sectional survey, all treatments are reported as effective by patients. These findings support a prominent placebo effect in Ménière's disease and highlight challenges in studying treatment outcomes; there is a critical need to better understand Ménière's disease. Clinic for Otorhinolaryngology zora Otorhinolaryngology, General Medicine zora Ward Bryan joint author Wettstein Vincent joint author Golding John joint author Corallo Giulia joint author Nuti Daniele joint author Trabalzini Franco joint author Mandala Marco joint author The Journal of International Advanced Otology 15(1):112-117 https://www.zora.uzh.ch/id/eprint/172052/1/112-1172.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/172052/1/112-1172.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Ward Bryan joint author ZORA 700 1- Wettstein Vincent joint author ZORA 700 1- Golding John joint author ZORA 700 1- Corallo Giulia joint author ZORA 700 1- Nuti Daniele joint author ZORA 700 1- Trabalzini Franco joint author ZORA 700 1- Mandala Marco joint author ZORA 773 0- The Journal of International Advanced Otology 15(1):112-117 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article openAccess