cam a22 5 4500 569364191 CHVBK 20201009180550.0 m d cr |n |||||||| 190411s2019 gw |||| s 0 0|eng d 978-3-030-12040-5 978-3-030-12039-9 (print) 978-3-030-12041-2 (print) 978-3-030-12042-9 (print) 10.1007/978-3-030-12040-5 doi (SERSOL)ssj0002137441 (WaSeSS)ssj0002137441 WaSeSS QH301-705 PSA bicssc SCI086000 bisacsh 570 23 Thymus Transcriptome and Cell Biology [Elektronische Daten] edited by Geraldo A. Passos 1st ed. 2019. Cham Springer International Publishing Imprint: Springer 2019 1 online resource (XVII, 318 p. 30 illus., 23 illus. in color.) online resource text txt rdacontent/ger computer c rdamedia/ger online resource cr rdacarrier/ger text file PDF rda 1. History of the thymus: From a vestigial organ to the programming of immunological self-tolerance -- 2. Thymus Ontogeny and Development -- 3. The Ins and Outs of Thymic Epithelial Cell Differentiation and Function -- 4. T-Cell Development: From T-Lineage Specification to Intrathymic Maturation -- 5. Intrathymic cell migration: implications in thymocyte development and T-cell repertoire formation -- 6. Thymic crosstalk: an overview of the complex cellular interactions that control the establishment of T-cell tolerance -- 7. The Autoimmune Regulator (AIRE) gene, the master activator of self-antigen expression in the thymus -- 8. Aire Mutations and Autoimmune Diseases -- 9. The thymus as a mirror of the body's gene expression -- 10. Functional genomics of the infant human thymus: Aire and minipuberty -- 11. Thymus transcriptome of TGF-β superfamily -- 12. Development of thymic regulatory T lymphocytes -- 13. Adding insult to injury: improving the regenerative capacity of the aged thymus following clinically induced damage -- 14. Thymus rejuvenation after autologous hematopoietic stem cell transplantation in patients with autoimmune diseases. Lizenzbedingungen können den Zugang einschränken. License restrictions may limit access. This volume focuses on challenging field in biomedicine that is the genetic control of central immune tolerance. It covers the thymus development, their cellular components and their respective function, the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus, the Autoimmune regulator (Aire) gene, the mutations in this gene and manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. The thymus gland is a lymphoid organ implicated in the maturation, differentiation and selection of T cells. This organ is gained more and more attention in different biomedical research labs worldwide due to its function that is associated with the control of immune homeostasis in the body, establishing the central immune tolerance and preventing the onset of autoimmune diseases. Systems biology Human genetics Endocrinology Cell biology Passos Geraldo A. editor edt http://id SpringerLink (Online service) Printed edition 9783030120399 Printed edition 9783030120412 Printed edition 9783030120429 https://link.springer.com/10.1007/978-3-030-12040-5 Uni Basel: Volltext https://link.springer.com/10.1007/978-3-030-12040-5 Uni Bern: Volltext BK020053 XK020053 XK020000 Springer Biomedical and Life Sciences eBooks 2019 English/International E-Books von 360MarcUpdates PSA thema IDSBB A145 A145 145VT NELA1451907 IDSBB B405 B405 405VT NELB4051907 IDSBB 700 1- Passos Geraldo A. editor edt http://id IDSBB 710 2- SpringerLink (Online service) IDSBB 776 08 Printed edition 9783030120399 IDSBB 776 08 Printed edition 9783030120412 IDSBB 776 08 Printed edition 9783030120429 IDSBB 856 40 https://link.springer.com/10.1007/978-3-030-12040-5 Uni Basel: Volltext IDSBB 856 40 https://link.springer.com/10.1007/978-3-030-12040-5 Uni Bern: Volltext