caa a22 4500 605455902 CHVBK 20210128100215.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00167-014-2997-2 doi (NATIONALLICENCE)springer-10.1007/s00167-014-2997-2 Cartilage MRI relaxation times after arthroscopic partial medial meniscectomy reveal localized degeneration [Elektronische Daten] [Richard Souza, Samuel Wu, Lee Morse, K. Subburaj, Christina Allen, Brian Feeley] Purpose: Little is known about the early changes in cartilage composition and tibiofemoral kinematics following partial meniscectomy. The purpose of this study was to determine the effects of partial meniscectomy on cartilage compositional properties using T1ρ and T2 relaxation time mapping and to assess changes in tibiofemoral kinematics. It is hypothesize that abnormal tibiofemoral kinematics and relaxation time elevation (a reflection of changes in cartilage biochemical composition) in the weight-bearing regions of the knees following meniscectomy will be observed. Methods: Nine patients (7 males and 2 females; mean age, 48.6±10.8years; BMI=27.3±3.8kg/m2) with tears of the posterior horn of the medial meniscus underwent arthroscopic partial meniscectomy. Pre-surgical and 6 months post-surgical MRIs were obtained in all subjects to evaluate cartilage relaxation times and tibiofemoral kinematics. Paired t tests were performed to determine significant changes in cartilage relaxation times from baseline. Results: T1ρ relaxation time in the region of the medial femoral condyle directly adjacent to the resection showed an increase of 7.4% at 6months (p=0.02). T2 relaxation times in both the medial and lateral tibial plateaus showed significant elevation at 6months. Consistent kinematic trends were not found in post-meniscectomized knees. Conclusions: These results suggest that arthroscopic partial meniscectomy affects the biochemical composition of articular cartilage in the knee in as early as 6months. The largest responses were observed in the weight-bearing regions and the cartilage immediately adjacent to the resection. This suggests that the loading environment has been altered enough to result in cartilage compositional changes in a very brief period of time following meniscectomy. Level of evidence: IV. Springer-Verlag Berlin Heidelberg, 2014 T1rho relaxation times nationallicence T2 relaxation times nationallicence Kinematics nationallicence Osteoarthritis nationallicence Souza Richard Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, 185 Berry Street, Suite 350, 94107, San Francisco, CA, USA aut Wu Samuel Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA aut Morse Lee Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA aut Subburaj K. Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA aut Allen Christina Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA aut Feeley Brian Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/1(2015-01-01), 188-197 0942-2056 23:1<188 2015 23 167 https://doi.org/10.1007/s00167-014-2997-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-014-2997-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Souza Richard Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, 185 Berry Street, Suite 350, 94107, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Wu Samuel Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Morse Lee Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Subburaj K. Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Allen Christina Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Feeley Brian Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/1(2015-01-01), 188-197 0942-2056 23:1<188 2015 23 167