Why menisci show higher healing rate when repaired during ACL reconstruction? Growth factors release can be the explanation
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 605455996 | ||
| 003 | CHVBK | ||
| 005 | 20210128100215.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150101xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00167-013-2712-8 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00167-013-2712-8 | ||
| 245 | 0 | 0 | |a Why menisci show higher healing rate when repaired during ACL reconstruction? Growth factors release can be the explanation |h [Elektronische Daten] |c [L. de Girolamo, E. Galliera, P. Volpi, M. Denti, G. Dogliotti, A. Quaglia, P. Cabitza, M. Corsi Romanelli, P. Randelli] |
| 520 | 3 | |a Purpose: Healing rate of meniscus repair is higher when the suture is associated with anterior cruciate ligament reconstruction. A possible explanation can be a different pattern of release of growth factors between anterior cruciate ligament reconstruction and isolated meniscus surgery. Hypothesis of this study is that the concentrations of bFGF, TGF-β and platelet-derived growth factor (PDGF) in joint fluid, immediately after single-bundle anterior cruciate ligament reconstruction and arthroscopic partial meniscectomy, can be different. Methods: Twenty consecutive patients underwent partial medial meniscectomy and twenty consecutive patients underwent single-bundle anterior cruciate ligament reconstruction with hamstring grafts were enrolled in the study. Thirty minutes after the end of the surgical procedure, a sample of joint fluid, as well of venous blood, was collected from all the patients. Concentrations of growth factors were determined by enzyme-linked immunosorbent assay. Results: The peripheral blood concentration of TGF-β, bFGF and PDGF was comparable between partial meniscectomy and anterior cruciate ligament reconstruction groups. No differences between the two surgical techniques were also found in term of TGF-β and bFGF joint fluid concentration, whereas joint PDGF concentration of anterior cruciate ligament reconstruction patients was significantly higher than the one found in partial meniscectomy patients. Conclusions: A significant growth factors release was detected in the knee joint during arthroscopic surgery. PDGF concentration was significantly higher in anterior cruciate ligament reconstructed knee than in the meniscectomy group. PDGF can play an important role enhancing the healing response of meniscus suture and can be one of the biological reasons of the higher meniscal healing rate in anterior cruciate ligament reconstructed knee. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2013 | ||
| 690 | 7 | |a Meniscal repair |2 nationallicence | |
| 690 | 7 | |a ACL reconstruction |2 nationallicence | |
| 690 | 7 | |a Platelet-derived growth factor |2 nationallicence | |
| 690 | 7 | |a Basic fibroblastic growth factor |2 nationallicence | |
| 690 | 7 | |a Transforming growth factor-β |2 nationallicence | |
| 690 | 7 | |a Tissue healing |2 nationallicence | |
| 690 | 7 | |a Tissue remodelling |2 nationallicence | |
| 700 | 1 | |a de Girolamo |D L. |u IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi, 4, Milan, Italy |4 aut | |
| 700 | 1 | |a Galliera |D E. |u IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi, 4, Milan, Italy |4 aut | |
| 700 | 1 | |a Volpi |D P. |u Istituto Clinico Humanitas IRCCS, Rozzano, Italy |4 aut | |
| 700 | 1 | |a Denti |D M. |u Istituto Clinico Humanitas IRCCS, Rozzano, Italy |4 aut | |
| 700 | 1 | |a Dogliotti |D G. |u Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy |4 aut | |
| 700 | 1 | |a Quaglia |D A. |u Istituto Clinico Humanitas IRCCS, Rozzano, Italy |4 aut | |
| 700 | 1 | |a Cabitza |D P. |u Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy |4 aut | |
| 700 | 1 | |a Corsi Romanelli |D M. |u Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy |4 aut | |
| 700 | 1 | |a Randelli |D P. |u Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy |4 aut | |
| 773 | 0 | |t Knee Surgery, Sports Traumatology, Arthroscopy |d Springer Berlin Heidelberg |g 23/1(2015-01-01), 90-96 |x 0942-2056 |q 23:1<90 |1 2015 |2 23 |o 167 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00167-013-2712-8 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00167-013-2712-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a de Girolamo |D L. |u IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi, 4, Milan, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Galliera |D E. |u IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi, 4, Milan, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Volpi |D P. |u Istituto Clinico Humanitas IRCCS, Rozzano, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Denti |D M. |u Istituto Clinico Humanitas IRCCS, Rozzano, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dogliotti |D G. |u Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Quaglia |D A. |u Istituto Clinico Humanitas IRCCS, Rozzano, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cabitza |D P. |u Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Corsi Romanelli |D M. |u Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Randelli |D P. |u Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Knee Surgery, Sports Traumatology, Arthroscopy |d Springer Berlin Heidelberg |g 23/1(2015-01-01), 90-96 |x 0942-2056 |q 23:1<90 |1 2015 |2 23 |o 167 | ||