caa a22 4500 605455996 CHVBK 20210128100215.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00167-013-2712-8 doi (NATIONALLICENCE)springer-10.1007/s00167-013-2712-8 Why menisci show higher healing rate when repaired during ACL reconstruction? Growth factors release can be the explanation [Elektronische Daten] [L. de Girolamo, E. Galliera, P. Volpi, M. Denti, G. Dogliotti, A. Quaglia, P. Cabitza, M. Corsi Romanelli, P. Randelli] Purpose: Healing rate of meniscus repair is higher when the suture is associated with anterior cruciate ligament reconstruction. A possible explanation can be a different pattern of release of growth factors between anterior cruciate ligament reconstruction and isolated meniscus surgery. Hypothesis of this study is that the concentrations of bFGF, TGF-β and platelet-derived growth factor (PDGF) in joint fluid, immediately after single-bundle anterior cruciate ligament reconstruction and arthroscopic partial meniscectomy, can be different. Methods: Twenty consecutive patients underwent partial medial meniscectomy and twenty consecutive patients underwent single-bundle anterior cruciate ligament reconstruction with hamstring grafts were enrolled in the study. Thirty minutes after the end of the surgical procedure, a sample of joint fluid, as well of venous blood, was collected from all the patients. Concentrations of growth factors were determined by enzyme-linked immunosorbent assay. Results: The peripheral blood concentration of TGF-β, bFGF and PDGF was comparable between partial meniscectomy and anterior cruciate ligament reconstruction groups. No differences between the two surgical techniques were also found in term of TGF-β and bFGF joint fluid concentration, whereas joint PDGF concentration of anterior cruciate ligament reconstruction patients was significantly higher than the one found in partial meniscectomy patients. Conclusions: A significant growth factors release was detected in the knee joint during arthroscopic surgery. PDGF concentration was significantly higher in anterior cruciate ligament reconstructed knee than in the meniscectomy group. PDGF can play an important role enhancing the healing response of meniscus suture and can be one of the biological reasons of the higher meniscal healing rate in anterior cruciate ligament reconstructed knee. Springer-Verlag Berlin Heidelberg, 2013 Meniscal repair nationallicence ACL reconstruction nationallicence Platelet-derived growth factor nationallicence Basic fibroblastic growth factor nationallicence Transforming growth factor-β nationallicence Tissue healing nationallicence Tissue remodelling nationallicence de Girolamo L. IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi, 4, Milan, Italy aut Galliera E. IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi, 4, Milan, Italy aut Volpi P. Istituto Clinico Humanitas IRCCS, Rozzano, Italy aut Denti M. Istituto Clinico Humanitas IRCCS, Rozzano, Italy aut Dogliotti G. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy aut Quaglia A. Istituto Clinico Humanitas IRCCS, Rozzano, Italy aut Cabitza P. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy aut Corsi Romanelli M. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy aut Randelli P. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/1(2015-01-01), 90-96 0942-2056 23:1<90 2015 23 167 https://doi.org/10.1007/s00167-013-2712-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-013-2712-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Girolamo L. IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi, 4, Milan, Italy aut NATIONALLICENCE 700 1- Galliera E. IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi, 4, Milan, Italy aut NATIONALLICENCE 700 1- Volpi P. Istituto Clinico Humanitas IRCCS, Rozzano, Italy aut NATIONALLICENCE 700 1- Denti M. Istituto Clinico Humanitas IRCCS, Rozzano, Italy aut NATIONALLICENCE 700 1- Dogliotti G. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy aut NATIONALLICENCE 700 1- Quaglia A. Istituto Clinico Humanitas IRCCS, Rozzano, Italy aut NATIONALLICENCE 700 1- Cabitza P. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy aut NATIONALLICENCE 700 1- Corsi Romanelli M. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy aut NATIONALLICENCE 700 1- Randelli P. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/1(2015-01-01), 90-96 0942-2056 23:1<90 2015 23 167