caa a22 4500 605456151 CHVBK 20210128100216.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00167-014-3310-0 doi (NATIONALLICENCE)springer-10.1007/s00167-014-3310-0 Meniscal allograft transplantation in a symptomatic meniscal deficient knee: a systematic review [Elektronische Daten] [Nick Smith, Nicola MacKay, Matthew Costa, Tim Spalding] Purpose: The primary objective of this study was to perform an updated systematic review and meta-analysis of meniscal allograft transplantation using patient reported outcome measures at final follow-up as the outcome tool. The secondary objective was to provide an up to date review of the indications, associated procedures, operative technique, rehabilitation, failures, complications, radiological outcomes, and graft healing. Methods: Medline, Embase and CENTRAL databases, trials registries, and Web-of Science were searched for studies using pre-defined eligibility criteria. Included studies were reviewed with Lysholm, International Knee Documentation Committee (IKDC) and Tegner scores, failures and complications pooled. Studies were also qualitatively assessed. Results: There were 1,332 patients (1,374 knees) in 35 studies eligible for analysis. The mean follow-up was 5.1years. Across all studies, Lysholm scores improved from 55.7 to 81.3, IKDC scores from 47.0 to 70.0, and Tegner activity scores from 3.1 to 4.7 between pre-operative and final follow-up assessments, respectively. The mean failure rate across all studies was 10.6% at 4.8years, and complication rate was 13.9% at 4.7years. There is a high risk of bias across the studies due to study design and missing outcomes. Conclusion: Based on current evidence, meniscal allograft transplantation appears to be an effective intervention for patients with a symptomatic meniscal deficient knee. This should ideally be confirmed with a randomised controlled trial. There is not currently enough evidence to determine whether it is chondroprotective. European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA), 2014 Meniscal allograft transplantation nationallicence Systematic review nationallicence Meniscectomy nationallicence Patient reported outcome measures nationallicence Smith Nick Clinical Sciences Research Laboratories, University of Warwick, Clifford Bridge Road, CV2 2DX, Coventry, UK aut MacKay Nicola Western Infirmary Glasgow, Dumbarton Road, G11 6NT, Glasgow, UK aut Costa Matthew Clinical Trials Unit, Warwick Medical School, University of Warwick, CV4 7AL, Coventry, UK aut Spalding Tim University Hospitals Coventry and Warwickshire, 5th floor UHCW, Clifford Bridge Road, CV2 2DX, Coventry, UK aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/1(2015-01-01), 270-279 0942-2056 23:1<270 2015 23 167 https://doi.org/10.1007/s00167-014-3310-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-014-3310-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Smith Nick Clinical Sciences Research Laboratories, University of Warwick, Clifford Bridge Road, CV2 2DX, Coventry, UK aut NATIONALLICENCE 700 1- MacKay Nicola Western Infirmary Glasgow, Dumbarton Road, G11 6NT, Glasgow, UK aut NATIONALLICENCE 700 1- Costa Matthew Clinical Trials Unit, Warwick Medical School, University of Warwick, CV4 7AL, Coventry, UK aut NATIONALLICENCE 700 1- Spalding Tim University Hospitals Coventry and Warwickshire, 5th floor UHCW, Clifford Bridge Road, CV2 2DX, Coventry, UK aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/1(2015-01-01), 270-279 0942-2056 23:1<270 2015 23 167