caa a22 4500 605456585 CHVBK 20210128100218.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00167-014-3066-6 doi (NATIONALLICENCE)springer-10.1007/s00167-014-3066-6 Monitoring concussion in a knocked-out boxer by CSF biomarker analysis [Elektronische Daten] [Sanna Neselius, Helena Brisby, Fredrik Granholm, Henrik Zetterberg, Kaj Blennow] Concussion is common in many sports, and the incidence is increasing. The medical consequences after a sport-related concussion have received increased attention in recent years since it is known that concussions cause axonal and glial damage, which disturbs the cerebral physiology and makes the brain more vulnerable for additional concussions. This study reports on a knocked-out amateur boxer in whom cerebrospinal fluid (CSF) neurofilament light (NFL) protein, reflecting axonal damage, was used to identify and monitor brain damage. CSF NFL was markedly increased during 36weeks, suggesting that neuronal injury persists longer than expected after a concussion. CSF biomarker analysis may be valuable in the medical counselling of concussed athletes and in return-to-play considerations. Level of evidence IV Springer-Verlag Berlin Heidelberg, 2014 Concussion nationallicence Traumatic brain injury (TBI) nationallicence Mild traumatic brain injury nationallicence Boxing nationallicence Neselius Sanna Department of Orthopaedics, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden aut Brisby Helena Department of Orthopaedics, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden aut Granholm Fredrik Department of Emergency Medicine, Sundsvall County Hospital, Sundsvall, Sweden aut Zetterberg Henrik Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden aut Blennow Kaj Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/9(2015-09-01), 2536-2539 0942-2056 23:9<2536 2015 23 167 https://doi.org/10.1007/s00167-014-3066-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-014-3066-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Neselius Sanna Department of Orthopaedics, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden aut NATIONALLICENCE 700 1- Brisby Helena Department of Orthopaedics, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden aut NATIONALLICENCE 700 1- Granholm Fredrik Department of Emergency Medicine, Sundsvall County Hospital, Sundsvall, Sweden aut NATIONALLICENCE 700 1- Zetterberg Henrik Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden aut NATIONALLICENCE 700 1- Blennow Kaj Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/9(2015-09-01), 2536-2539 0942-2056 23:9<2536 2015 23 167