Opioids as an alternative to amide-type local anaesthetics for intra-articular application
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| 024 | 7 | 0 | |a 10.1007/s00167-014-2989-2 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00167-014-2989-2 | ||
| 245 | 0 | 0 | |a Opioids as an alternative to amide-type local anaesthetics for intra-articular application |h [Elektronische Daten] |c [Irina Ickert, Monika Herten, Melanie Vogl, Christoph Ziskoven, Christoph Zilkens, Rüdiger Krauspe, Jörn Kircher] |
| 520 | 3 | |a Purpose: Recently, the safety profile of local anaesthetics in intra-articular use became into focus of investigation. Opioid drugs have a different mode of action and may be a safe and potent alternative for intra-articular application. The purpose of this in vitro study is to provide evidence for significant chondrotoxicity of amide-type local anaesthetics even after short-term application on human chondrocytes and to demonstrate the absence of such negative effects for opioids [morphine, morphine-6-glucuronide (M6G)]. Method: Visually intact cartilage explants of human, mainly osteoarthritic joints (n=9), were harvested and cultivated in monolayer for expansion and transferred into alginate bead. The beads were incubated for increasing incubation times (15min, 1 and 4h) in decreasing concentrations (full, ½, ¼ for 15min) of bupivacaine, ropivacaine, morphine, M6G or saline control. Adenosine triphosphate content of 798 beads was measured 3days post-incubation to assess cell viability. Results: A clear ranking of cytotoxic potency: bupivacaine>ropivacaine>morphine=M6G=saline was observed. Results reveal a dose- and time-dependent manner of cytotoxic effects on human chondrocytes for bupivacaine and ropivacaine but not for opioids. Cell viability after exposure to morphine and M6G was comparable to exposure to saline. Conclusion: The results confirm dose- and time-dependent cytotoxic effects on human chondrocytes for amide-type local anaesthetics. This study confirms the safety of morphine and M6G in terms of an absence of cytotoxic effects after intra-articular application, making them safe potential alternatives in clinical practice. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2014 | ||
| 690 | 7 | |a Local anaesthetics |2 nationallicence | |
| 690 | 7 | |a Morphine |2 nationallicence | |
| 690 | 7 | |a Morphine-6-glucuronide |2 nationallicence | |
| 690 | 7 | |a Chondrocytes |2 nationallicence | |
| 690 | 7 | |a Cell viability |2 nationallicence | |
| 690 | 7 | |a Joint |2 nationallicence | |
| 700 | 1 | |a Ickert |D Irina |u Department of Orthopedics, University Hospital, Heinrich-Heine-University, Duesseldorf, Germany |4 aut | |
| 700 | 1 | |a Herten |D Monika |u Department of Vascular and Endovascular Surgery, University Hospital, Albert-Schweitzer-Campus 1, Building W30, 48149, Münster, Germany |4 aut | |
| 700 | 1 | |a Vogl |D Melanie |u Department of Orthopedics, University Hospital, Heinrich-Heine-University, Duesseldorf, Germany |4 aut | |
| 700 | 1 | |a Ziskoven |D Christoph |u Department of Orthopedics, University Hospital, Heinrich-Heine-University, Duesseldorf, Germany |4 aut | |
| 700 | 1 | |a Zilkens |D Christoph |u Department of Orthopedics, University Hospital, Heinrich-Heine-University, Duesseldorf, Germany |4 aut | |
| 700 | 1 | |a Krauspe |D Rüdiger |u Department of Orthopedics, University Hospital, Heinrich-Heine-University, Duesseldorf, Germany |4 aut | |
| 700 | 1 | |a Kircher |D Jörn |u Department of Orthopedics, University Hospital, Heinrich-Heine-University, Duesseldorf, Germany |4 aut | |
| 773 | 0 | |t Knee Surgery, Sports Traumatology, Arthroscopy |d Springer Berlin Heidelberg |g 23/9(2015-09-01), 2674-2681 |x 0942-2056 |q 23:9<2674 |1 2015 |2 23 |o 167 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00167-014-2989-2 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00167-014-2989-2 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ickert |D Irina |u Department of Orthopedics, University Hospital, Heinrich-Heine-University, Duesseldorf, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Herten |D Monika |u Department of Vascular and Endovascular Surgery, University Hospital, Albert-Schweitzer-Campus 1, Building W30, 48149, Münster, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vogl |D Melanie |u Department of Orthopedics, University Hospital, Heinrich-Heine-University, Duesseldorf, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ziskoven |D Christoph |u Department of Orthopedics, University Hospital, Heinrich-Heine-University, Duesseldorf, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zilkens |D Christoph |u Department of Orthopedics, University Hospital, Heinrich-Heine-University, Duesseldorf, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Krauspe |D Rüdiger |u Department of Orthopedics, University Hospital, Heinrich-Heine-University, Duesseldorf, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kircher |D Jörn |u Department of Orthopedics, University Hospital, Heinrich-Heine-University, Duesseldorf, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Knee Surgery, Sports Traumatology, Arthroscopy |d Springer Berlin Heidelberg |g 23/9(2015-09-01), 2674-2681 |x 0942-2056 |q 23:9<2674 |1 2015 |2 23 |o 167 | ||