caa a22 4500 605456739 CHVBK 20210128100219.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00167-013-2743-1 doi (NATIONALLICENCE)springer-10.1007/s00167-013-2743-1 Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration [Elektronische Daten] [G. Filardo, E. Kon, A. Roffi, B. Di Matteo, M. Merli, M. Marcacci] Purpose: The aim of this review was to analyze the available evidence on the clinical application of this biological approach for the injective treatment of cartilage lesions and joint degeneration, together with preclinical studies to support the rationale for the use of platelet concentrates, to shed some light and give indications on what to treat and what to expect from intra-articular injections of platelet-rich plasma (PRP). Methods: All in vitro, in vivo preclinical and clinical studies on PRP injective treatment in the English language concerning the effect of PRP on cartilage, synovial tissue, menisci, and mesenchymal stem cells were considered. A systematic review on the PubMed database was performed using the following words: (platelet-rich plasma or PRP or platelet concentrate or platelet lysate or platelet supernatant) and (cartilage or chondrocytes or synoviocytes or menisci or mesenchymal stem cells). Results: Fifty-nine articles met the inclusion criteria: 26 were in vitro, 9 were in vivo, 2 were both in vivo and in vitro, and 22 were clinical studies. The analysis showed an increasing number of published studies over time. Preclinical evidence supports the use of PRP injections that might promote a favourable environment for joint tissues healing. Only a few high-quality clinical trials have been published, which showed a clinical improvement limited over time and mainly documented in younger patients not affected by advanced knee degeneration. Conclusions: Besides the limits and sometimes controversial findings, the preclinical literature shows an overall support toward this PRP application. An intra-articular injection does not just target cartilage; instead, PRP might influence the entire joint environment, leading to a short-term clinical improvement. Many biological variables might influence the clinical outcome and have to be studied to optimize PRP injective treatment of cartilage degeneration and osteoarthritis. Level of evidence: IV. The Author(s), 2013 PRP nationallicence Growth factors nationallicence Knee nationallicence Intra-articular nationallicence Injection nationallicence Cartilage nationallicence Filardo G. Nano-Biotechnology Laboratory, II Orthopaedic Clinic, Rizzoli Orthopaedic Insitute, Via di Barbiano n. 1/10, 40136, Bologna, Italy aut Kon E. Nano-Biotechnology Laboratory, II Orthopaedic Clinic, Rizzoli Orthopaedic Insitute, Via di Barbiano n. 1/10, 40136, Bologna, Italy aut Roffi A. Nano-Biotechnology Laboratory, II Orthopaedic Clinic, Rizzoli Orthopaedic Insitute, Via di Barbiano n. 1/10, 40136, Bologna, Italy aut Di Matteo B. Biomechanics Laboratory, II Orthopaedic Clinic, Rizzoli Orthopaedic Insitute, Via di Barbiano n. 1/10, 40136, Bologna, Italy aut Merli M. Biomechanics Laboratory, II Orthopaedic Clinic, Rizzoli Orthopaedic Insitute, Via di Barbiano n. 1/10, 40136, Bologna, Italy aut Marcacci M. Biomechanics Laboratory, II Orthopaedic Clinic, Rizzoli Orthopaedic Insitute, Via di Barbiano n. 1/10, 40136, Bologna, Italy aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/9(2015-09-01), 2459-2474 0942-2056 23:9<2459 2015 23 167 https://doi.org/10.1007/s00167-013-2743-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-013-2743-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Filardo G. Nano-Biotechnology Laboratory, II Orthopaedic Clinic, Rizzoli Orthopaedic Insitute, Via di Barbiano n. 1/10, 40136, Bologna, Italy aut NATIONALLICENCE 700 1- Kon E. Nano-Biotechnology Laboratory, II Orthopaedic Clinic, Rizzoli Orthopaedic Insitute, Via di Barbiano n. 1/10, 40136, Bologna, Italy aut NATIONALLICENCE 700 1- Roffi A. Nano-Biotechnology Laboratory, II Orthopaedic Clinic, Rizzoli Orthopaedic Insitute, Via di Barbiano n. 1/10, 40136, Bologna, Italy aut NATIONALLICENCE 700 1- Di Matteo B. Biomechanics Laboratory, II Orthopaedic Clinic, Rizzoli Orthopaedic Insitute, Via di Barbiano n. 1/10, 40136, Bologna, Italy aut NATIONALLICENCE 700 1- Merli M. Biomechanics Laboratory, II Orthopaedic Clinic, Rizzoli Orthopaedic Insitute, Via di Barbiano n. 1/10, 40136, Bologna, Italy aut NATIONALLICENCE 700 1- Marcacci M. Biomechanics Laboratory, II Orthopaedic Clinic, Rizzoli Orthopaedic Insitute, Via di Barbiano n. 1/10, 40136, Bologna, Italy aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/9(2015-09-01), 2459-2474 0942-2056 23:9<2459 2015 23 167