caa a22 4500 605456887 CHVBK 20210128105154.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00167-014-3077-3 doi (NATIONALLICENCE)springer-10.1007/s00167-014-3077-3 The influence of sex hormones on anterior cruciate ligament rupture: female study [Elektronische Daten] [Lazar Stijak, Marko Kadija, Vuk Djulejić, Milan Aksić, Nataša Petronijević, Branka Marković, Vidosava Radonjić, Marko Bumbaširević, Branislav Filipović] Purpose: The purpose of this study was to determine the difference in the concentrations of testosterone, 17-β estradiol and progesterone between female patients with and without ACL rupture and the possible effect of these hormones on generalised joint laxity. Methods: Female subjects with non-contact knee joint injury were included in this study. They were divided into two groups: the examined group, consisting of female subjects with ACL rupture, and the control group, consisting of female patients without ACL rupture. In the next step, the patients from these two groups were paired off on the basis of three factors: the level of professional sports involvement (including the type of sports activity), the side of the body where the injury had occurred (left or right) and the age of the subjects. In the end, there were 12 pairs (24 subjects). The concentrations of sex hormones were established from saliva specimens with the aid of the Salimetrics enzyme immunoassay. Generalised joint laxity was tested with the aid of the "laxity score” according to Beighton, Solomon and Soskolne. Results: Female subjects with ACL rupture had significantly lower concentrations of testosterone (p<0.01), significantly lower concentrations of 17-β estradiol (p<0.05) and significantly lower concentrations of progesterone (p<0.01) than female subjects with intact ACL. Conclusions: Decreased concentrations of testosterone, 17-β estradiol or progesterone may be a risk factor leading to ACL rupture. The concentrations of these hormones do not affect generalised joint laxity. Additional research on a larger group of patients is necessary to further determine the effects of these hormones on generalised joint laxity and ACL ruptures. Young female athletes with lower concentrations of sex hormones are more prone to anterior cruciate ligament rupture which is why they need to reduce their sports activities during the pre-ovulatory phase of the menstrual cycle, when these concentrations are additionally reduced. Level of evidence: III. Springer-Verlag Berlin Heidelberg, 2014 Anterior cruciate ligament nationallicence Testosterone nationallicence 17-β Estradiol nationallicence Progesterone nationallicence Joint laxity nationallicence Stijak Lazar Department of Anatomy, School of Medicine, University of Belgrade, dr Subotića 4, 11000, Belgrade, Serbia aut Kadija Marko Clinic for Orthopedic Surgery and Traumatology, Clinical Center of Serbia, Pasterova 2, 11000, Belgrade, Serbia aut Djulejić Vuk Department of Anatomy, School of Medicine, University of Belgrade, dr Subotića 4, 11000, Belgrade, Serbia aut Aksić Milan Department of Anatomy, School of Medicine, University of Belgrade, dr Subotića 4, 11000, Belgrade, Serbia aut Petronijević Nataša Institute of Biochemistry, School of Medicine, University of Belgrade, Pasterova 2, 11000, Belgrade, Serbia aut Marković Branka Faculty of Sport and Physical Education, University of Belgrade, Blagoja Parovića 156, 11000, Belgrade, Serbia aut Radonjić Vidosava Department of Anatomy, School of Medicine, University of Belgrade, dr Subotića 4, 11000, Belgrade, Serbia aut Bumbaširević Marko Clinic for Orthopedic Surgery and Traumatology, Clinical Center of Serbia, Pasterova 2, 11000, Belgrade, Serbia aut Filipović Branislav Department of Anatomy, School of Medicine, University of Belgrade, dr Subotića 4, 11000, Belgrade, Serbia aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/9(2015-09-01), 2742-2749 0942-2056 23:9<2742 2015 23 167 https://doi.org/10.1007/s00167-014-3077-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-014-3077-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stijak Lazar Department of Anatomy, School of Medicine, University of Belgrade, dr Subotića 4, 11000, Belgrade, Serbia aut NATIONALLICENCE 700 1- Kadija Marko Clinic for Orthopedic Surgery and Traumatology, Clinical Center of Serbia, Pasterova 2, 11000, Belgrade, Serbia aut NATIONALLICENCE 700 1- Djulejić Vuk Department of Anatomy, School of Medicine, University of Belgrade, dr Subotića 4, 11000, Belgrade, Serbia aut NATIONALLICENCE 700 1- Aksić Milan Department of Anatomy, School of Medicine, University of Belgrade, dr Subotića 4, 11000, Belgrade, Serbia aut NATIONALLICENCE 700 1- Petronijević Nataša Institute of Biochemistry, School of Medicine, University of Belgrade, Pasterova 2, 11000, Belgrade, Serbia aut NATIONALLICENCE 700 1- Marković Branka Faculty of Sport and Physical Education, University of Belgrade, Blagoja Parovića 156, 11000, Belgrade, Serbia aut NATIONALLICENCE 700 1- Radonjić Vidosava Department of Anatomy, School of Medicine, University of Belgrade, dr Subotića 4, 11000, Belgrade, Serbia aut NATIONALLICENCE 700 1- Bumbaširević Marko Clinic for Orthopedic Surgery and Traumatology, Clinical Center of Serbia, Pasterova 2, 11000, Belgrade, Serbia aut NATIONALLICENCE 700 1- Filipović Branislav Department of Anatomy, School of Medicine, University of Belgrade, dr Subotića 4, 11000, Belgrade, Serbia aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/9(2015-09-01), 2742-2749 0942-2056 23:9<2742 2015 23 167 SWISSBIB 605456887