caa a22 4500 605456933 CHVBK 20210128100220.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00167-014-2962-0 doi (NATIONALLICENCE)springer-10.1007/s00167-014-2962-0 Efficacy of intraarticular application of ketamine or ketamine-levobupivacaine combination on post-operative pain after arthroscopic meniscectomy [Elektronische Daten] [Cengiz Isik, Abdullah Demirhan, Tevfik Yetis, Korgun Oktem, Hakan Sarman, Umit Tekelioglu, Turan Duran] Purpose: To evaluate the efficacy of intraarticular injection of ketamine or ketamine plus levobupivacaine on post-operative analgesia in patients undergoing arthroscopic meniscectomy. Methods: A prospective, randomized, double-blind study was performed on 60 patients aged 18-65years who planned to undergo elective arthroscopic meniscectomy. The patients were divided into three groups: the ketamine group (n=20) received 1.0mg/kg of intraarticular ketamine in 20ml of normal saline, the ketamine-levobupivacaine group (n=20) received 0.5mg/kg of intraarticular ketamine plus 50.0mg of 0.25% levobupivacaine in 20ml of normal saline, and the control group (n=20) received 20ml of intraarticular normal saline. A visual analogue scale (VAS) was used to determine the efficacy of analgesia at 1, 2, 4, 6, 8, 12, and 24h post-operatively. Results: There were statistically significant differences in the median VAS scores among the three groups according to Bonferroni adjustment at all time points (p<0.01), with the exception of 6 and 24h post-operatively. The median VAS scores at 1, 2, and 4h post-operatively were higher in the control group than in the two treatment groups (p<0.001). The median VAS scores in the control group at 1, 2, 4, 6, 8, and 12h post-operatively and those in the ketamine group at 4, 8, and 12h post-operatively were significantly higher than those in the ketamine-levobupivacaine group (p<0.05). Conclusion: Intraarticular ketamine provides effective post-operative analgesia. Addition of intraarticular levobupivacaine to ketamine may provide better amelioration of pain after outpatient arthroscopic meniscectomy. Level of evidence: I. Springer-Verlag Berlin Heidelberg, 2014 Arthroscopic meniscectomy nationallicence Intraarticular injection nationallicence Ketamine nationallicence Levobupivacaine nationallicence Isik Cengiz Department of Orthopedics and Traumatology, Faculty of Medicine, Abant İzzet Baysal University Medical School, Abant İzzet Baysal University, 14280, Gölköy, Bolu, Turkey aut Demirhan Abdullah Department of Anesthesiology and Reanimation, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey aut Yetis Tevfik Department of Orthopedics and Traumatology, Bolu Izzet Baysal State Hospital, Bolu, Turkey aut Oktem Korgun Department of Anesthesiology and Reanimation, Bolu Izzet Baysal State Hospital, Bolu, Turkey aut Sarman Hakan Department of Orthopedics and Traumatology, Faculty of Medicine, Abant İzzet Baysal University Medical School, Abant İzzet Baysal University, 14280, Gölköy, Bolu, Turkey aut Tekelioglu Umit Department of Anesthesiology and Reanimation, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey aut Duran Turan Department of Orthopedics and Traumatology, Bolu Izzet Baysal State Hospital, Bolu, Turkey aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/9(2015-09-01), 2721-2726 0942-2056 23:9<2721 2015 23 167 https://doi.org/10.1007/s00167-014-2962-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-014-2962-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Isik Cengiz Department of Orthopedics and Traumatology, Faculty of Medicine, Abant İzzet Baysal University Medical School, Abant İzzet Baysal University, 14280, Gölköy, Bolu, Turkey aut NATIONALLICENCE 700 1- Demirhan Abdullah Department of Anesthesiology and Reanimation, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey aut NATIONALLICENCE 700 1- Yetis Tevfik Department of Orthopedics and Traumatology, Bolu Izzet Baysal State Hospital, Bolu, Turkey aut NATIONALLICENCE 700 1- Oktem Korgun Department of Anesthesiology and Reanimation, Bolu Izzet Baysal State Hospital, Bolu, Turkey aut NATIONALLICENCE 700 1- Sarman Hakan Department of Orthopedics and Traumatology, Faculty of Medicine, Abant İzzet Baysal University Medical School, Abant İzzet Baysal University, 14280, Gölköy, Bolu, Turkey aut NATIONALLICENCE 700 1- Tekelioglu Umit Department of Anesthesiology and Reanimation, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey aut NATIONALLICENCE 700 1- Duran Turan Department of Orthopedics and Traumatology, Bolu Izzet Baysal State Hospital, Bolu, Turkey aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/9(2015-09-01), 2721-2726 0942-2056 23:9<2721 2015 23 167