caa a22 4500 605457867 CHVBK 20210128100225.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00167-013-2702-x doi (NATIONALLICENCE)springer-10.1007/s00167-013-2702-x Evolution of C-reactive protein values in the first month after anterior cruciate ligament reconstruction: reference values [Elektronische Daten] [Miguel Ruiz-Ibán, Jorge Díaz Heredia, Ignacio Cebreiro Martínez Val, Susana Alonso Güemes, Ricardo Cuéllar Gutiérrez, Sergi Sastre Solsona] Purpose: C-reactive protein (CRP) is often used as an infection marker in orthopaedic patients and in particular after anterior cruciate ligament (ACL) reconstruction surgery. The aim of this study is to obtain the reference values of CRP during the first month after an ACL reconstruction and to analyse the epidemiological and surgical parameters that affect these values. Methods: One hundred and twenty ACL reconstructions were included. A CRP determination was performed preoperatively and 1, 7, 14, 21 and 28days after surgery. CRP values under 5mg/l were considered to be normal. Results: One patient developed a septic arthritis in the second week postoperatively and was excluded. One hundred and seventeen patients [93 males and 24 females; mean age (standard deviation) 31.6years (7.6)] underwent 119 ACL reconstructions with different techniques and grafts. Preoperative CRP (n=119) was 1.80mg/ml (2.6). Mean values at 1, 7, 14, 21 and 28days were, respectively, 8.5mg/ml (11.6), 10.5mg/ml (17.0), 4.5mg/ml (3.43), 4.4mg/ml (7.59) and 3.4mg/ml (3.03). Multivariate analysis showed that males had postoperative CRP levels 1.7 higher than females (p<0.0001; 95% CI 1.8-2.5); the patients operated by less experienced surgeons had levels 2.5 times higher than those operated by a highly experienced surgeons (p=0.007; 95% CI 1.2-3.4) and that if microfracture of a chondral lesion was associated, the levels increased 1.9 times (p=0.021; 95% CI 1.1-3.4). Conclusions: There are significant variations in CRP levels after ACL reconstruction in half of patients without infectious complications. Males, patients operated by less experienced surgeons and those with chondral lesions treated with microfracture had increased postoperative CRP levels. CRP values up to five times the normal limit are common in the month after an ACL reconstruction and are not necessarily associated with infection, especially in these groups. Level of evidence: Diagnostic study, Level IV. Springer-Verlag Berlin Heidelberg, 2013 Anterior cruciate ligament nationallicence Anterior cruciate ligament reconstruction nationallicence C-reactive protein nationallicence Infection nationallicence Ruiz-Ibán Miguel Department of Orthopaedic Surgery, Servicio de COT, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain aut Díaz Heredia Jorge Department of Orthopaedic Surgery, Servicio de COT, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain aut Cebreiro Martínez Val Ignacio Department of Orthopaedic Surgery, Servicio de COT, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain aut Alonso Güemes Susana Department of Orthopaedic Surgery, Servicio de COT, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain aut Cuéllar Gutiérrez Ricardo Department of Orthopaedic Surgery, Hospital Universitario Donostia, San Sebastián, Spain aut Sastre Solsona Sergi Department of Orthopaedic Surgery, Hospital Clinic, Barcelona, Spain aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/3(2015-03-01), 763-769 0942-2056 23:3<763 2015 23 167 https://doi.org/10.1007/s00167-013-2702-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-013-2702-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ruiz-Ibán Miguel Department of Orthopaedic Surgery, Servicio de COT, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Díaz Heredia Jorge Department of Orthopaedic Surgery, Servicio de COT, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Cebreiro Martínez Val Ignacio Department of Orthopaedic Surgery, Servicio de COT, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Alonso Güemes Susana Department of Orthopaedic Surgery, Servicio de COT, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Cuéllar Gutiérrez Ricardo Department of Orthopaedic Surgery, Hospital Universitario Donostia, San Sebastián, Spain aut NATIONALLICENCE 700 1- Sastre Solsona Sergi Department of Orthopaedic Surgery, Hospital Clinic, Barcelona, Spain aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/3(2015-03-01), 763-769 0942-2056 23:3<763 2015 23 167