Peri-tunnel bone loss: does it affect early tendon graft to bone tunnel healing after ACL reconstruction?
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| 024 | 7 | 0 | |a 10.1007/s00167-013-2697-3 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00167-013-2697-3 | ||
| 245 | 0 | 0 | |a Peri-tunnel bone loss: does it affect early tendon graft to bone tunnel healing after ACL reconstruction? |h [Elektronische Daten] |c [Pauline Lui, Yuk Lee, Tsui Mok, Yau Cheuk] |
| 520 | 3 | |a Purpose: The clinical relevance and mechanisms of local bone loss early post-anterior cruciate ligament (ACL) reconstruction remain unclear. The early spatial and temporal changes of peri-tunnel bone, its molecular mechanisms and its relationships with graft-bone tunnel healing were investigated in a 12-week-old rat model. Methods: At various times, the reconstructed ACL complex was harvested for vivaCT imaging, biomechanical test, histology and immunohistochemical staining of CD68+ cells (a monocyte-macrophage lineage marker), MMP1 and MMP13. Results: The peri-tunnel bone resorbed simultaneously with improvement of graft-bone tunnel healing. There were 30.1±17.4, 46.8±10.5 and 81.5±12.3% loss of peri-tunnel BMD as well as 43.2±21.7, 78.7±8.5 and 92.4±17.7% loss of peri-tunnel bone volume/total volume (BV/TV) at week 6 at the distal femur, epiphysis and metaphysis of tibia, respectively. MMP1, MMP13 and CD68+ cells were expressed at the graft-bone tunnel interface and peri-tunnel bone and increased with time post-reconstruction at the tibia. The ultimate load and stiffness of the healing complex positively correlated with tibial tunnel bone formation and negatively correlated with tibial peri-tunnel bone. Tunnel BV/TV at the tibial metaphysis and epiphysis showed the highest correlation with ultimate load (ρ=0.591; p=0.001) and stiffness (ρ=0.427; p=0.026) of the complex, respectively. Conclusion: There was time-dependent loss of peri-tunnel bone early post-reconstruction, with the greatest loss occurring at the tibial metaphysis. This was consistent with high expression of MMP1, MMP13 and CD68+ cells at the graft-bone tunnel interface and the peri-tunnel region. The significant loss of peri-tunnel bone, though not critically affecting early tunnel healing, suggested the need to protect the knee joint early post-reconstruction. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2013 | ||
| 690 | 7 | |a Anterior cruciate ligament (ACL) reconstruction |2 nationallicence | |
| 690 | 7 | |a Peri-tunnel bone loss |2 nationallicence | |
| 690 | 7 | |a Tunnel healing |2 nationallicence | |
| 690 | 7 | |a MMP |2 nationallicence | |
| 690 | 7 | |a Monocyte-macrophage lineage marker |2 nationallicence | |
| 700 | 1 | |a Lui |D Pauline |u Headquarter, Hospital Authority, 9/F, Rumsey Street Multi-Storey Carpark Building, 2 Rumsey Street, Hong Kong SAR, China |4 aut | |
| 700 | 1 | |a Lee |D Yuk |u Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China |4 aut | |
| 700 | 1 | |a Mok |D Tsui |u Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China |4 aut | |
| 700 | 1 | |a Cheuk |D Yau |u Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China |4 aut | |
| 773 | 0 | |t Knee Surgery, Sports Traumatology, Arthroscopy |d Springer Berlin Heidelberg |g 23/3(2015-03-01), 740-751 |x 0942-2056 |q 23:3<740 |1 2015 |2 23 |o 167 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00167-013-2697-3 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00167-013-2697-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lui |D Pauline |u Headquarter, Hospital Authority, 9/F, Rumsey Street Multi-Storey Carpark Building, 2 Rumsey Street, Hong Kong SAR, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lee |D Yuk |u Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mok |D Tsui |u Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cheuk |D Yau |u Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Knee Surgery, Sports Traumatology, Arthroscopy |d Springer Berlin Heidelberg |g 23/3(2015-03-01), 740-751 |x 0942-2056 |q 23:3<740 |1 2015 |2 23 |o 167 | ||