caa a22 4500 605459185 CHVBK 20210128100232.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00167-014-2906-8 doi (NATIONALLICENCE)springer-10.1007/s00167-014-2906-8 Repair of articular cartilage defects in the knee with autologous iliac crest cartilage in a rabbit model [Elektronische Daten] [Lizhong Jing, Jiying Zhang, Huijie Leng, Qinwei Guo, Yuelin Hu] Purpose: To demonstrate that iliac crest cartilage may be used to repair articular cartilage defects in the knees of rabbits. Methods: Full-thickness cartilage defects were created in the medial femoral condyle on both knees of 36 New Zealand white rabbits. The 72 defects were randomly assigned to be repaired with ipsilateral iliac crest cartilage (Group I), osteochondral tissues removed at defect creation (Group II), or no treatment (negative control, Group III). Animals were killed at 6, 12, and 24weeks post-operatively. The repaired tissues were harvested for magnetic resonance imaging (MRI), histological studies (haematoxylin and eosin and immunohistochemical staining), and mechanical testing. Results: At 6weeks, the iliac crest cartilage graft was not yet well integrated with the surrounding articular cartilage, but at 12weeks, the graft deep zone had partial ossification. By 24weeks, the hyaline cartilage-like tissue was completely integrated with the surrounding articular cartilage. Osteochondral autografts showed more rapid healing than Group I at 6weeks and complete healing at 12weeks. Untreated defects were concave or partly filled with fibrous tissue throughout the study. MRI showed that Group I had slower integration with surrounding normal cartilage compared with Group II. The mechanical properties of Group I were significantly lower than those of Group II at 12weeks, but this difference was not significant at 24weeks. Conclusion: Iliac crest cartilage autografts were able to repair knee cartilage defects with hyaline cartilage and showed comparable results with osteochondral autografts in the rabbit model. Springer-Verlag Berlin Heidelberg, 2014 Iliac crest cartilage nationallicence Cartilage repair nationallicence Cartilage defect nationallicence Histology nationallicence Magnetic resonance imaging nationallicence Mechanical properties nationallicence Jing Lizhong Institute of Sports Medicine, Peking University Third Hospital, 100191, Beijing, People's Republic of China aut Zhang Jiying Institute of Sports Medicine, Peking University Third Hospital, 100191, Beijing, People's Republic of China aut Leng Huijie Orthopedic Surgery, Peking University Third Hospital, 100191, Beijing, People's Republic of China aut Guo Qinwei Institute of Sports Medicine, Peking University Third Hospital, 100191, Beijing, People's Republic of China aut Hu Yuelin Institute of Sports Medicine, Peking University Third Hospital, 100191, Beijing, People's Republic of China aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/4(2015-04-01), 1119-1127 0942-2056 23:4<1119 2015 23 167 https://doi.org/10.1007/s00167-014-2906-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-014-2906-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jing Lizhong Institute of Sports Medicine, Peking University Third Hospital, 100191, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Jiying Institute of Sports Medicine, Peking University Third Hospital, 100191, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Leng Huijie Orthopedic Surgery, Peking University Third Hospital, 100191, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Guo Qinwei Institute of Sports Medicine, Peking University Third Hospital, 100191, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Hu Yuelin Institute of Sports Medicine, Peking University Third Hospital, 100191, Beijing, People's Republic of China aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/4(2015-04-01), 1119-1127 0942-2056 23:4<1119 2015 23 167