caa a22 4500 605459428 CHVBK 20210128100234.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00167-014-2987-4 doi (NATIONALLICENCE)springer-10.1007/s00167-014-2987-4 The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee [Elektronische Daten] [Alberto Gobbi, Dnyanesh Lad, Georgios Karnatzikos] Purpose: To assess the outcome of intra-articular platelet-rich plasma (PRP) injections into the knee in patients with early stages of osteoarthritis (OA) and to determine whether cyclical dosing would affect the end result. Methods: This is a prospective, randomized study in which 93 patients (119 knees) were followed up for a minimum of 2years. Fifty knees were randomly selected prior to the first injection, to receive a second cycle at the completion of 1year. A cycle consisted of three injections, each given at a monthly interval. The outcome was assessed using Knee Injury and Osteoarthritis Outcome Score (KOOS), Visual Analogue Scale (VAS), Tegner and Marx scoring systems, recorded prior to the first injection and then at 12, 18 and 24months. Results: There was a significant improvement in all scores over time compared to the pre-treatment value (p<0.001). At 12months, both groups showed similar and significant improvement. At 18months, except for KOOS (Symptoms) and Tegner score, all other parameters showed a significant difference between the two groups in favour of the patients who had received the second cycle (p<0.001). At 2years, the scores declined in both groups but remained above the pre-treatment value with no significant difference between the groups despite the patients with two cycles showing higher mean values for all the scores. Conclusion: Intra-articular PRP injections into the knee for symptomatic early stages of OA are a valid treatment option. There is a significant reduction in pain and improvement in function after 12months, which can be further improved at 18months by annual repetition of the treatment. Although the beneficial effects are ill sustained at 2years, the results are encouraging when compared to the pre-treatment function. Level of evidence: II. Springer-Verlag Berlin Heidelberg, 2014 Platelet-rich plasma nationallicence Osteoarthritis nationallicence Knee nationallicence Dosage nationallicence Cyclic treatment nationallicence Gobbi Alberto O.A.S.I. Bioresearch Foundation, Via Amadeo 24, 20133, Milan, Italy aut Lad Dnyanesh O.A.S.I. Bioresearch Foundation, Via Amadeo 24, 20133, Milan, Italy aut Karnatzikos Georgios O.A.S.I. Bioresearch Foundation, Via Amadeo 24, 20133, Milan, Italy aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/8(2015-08-01), 2170-2177 0942-2056 23:8<2170 2015 23 167 https://doi.org/10.1007/s00167-014-2987-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-014-2987-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gobbi Alberto O.A.S.I. Bioresearch Foundation, Via Amadeo 24, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Lad Dnyanesh O.A.S.I. Bioresearch Foundation, Via Amadeo 24, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Karnatzikos Georgios O.A.S.I. Bioresearch Foundation, Via Amadeo 24, 20133, Milan, Italy aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/8(2015-08-01), 2170-2177 0942-2056 23:8<2170 2015 23 167