caa a22 4500 605459509 CHVBK 20210128100234.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00167-014-2964-y doi (NATIONALLICENCE)springer-10.1007/s00167-014-2964-y Significantly worse isokinetic hamstring-quadriceps ratio in patellofemoral compared to condylar defects 4years after autologous chondrocyte implantation [Elektronische Daten] [Sebastian Müller, Anja Hirschmüller, Christoph Erggelet, Nicholas Beckmann, Peter Kreuz] Purpose: Detailed biomechanical analysis including isokinetic muscle strength measurements after autologous chondrocyte implantation (ACI) are still rare, but might be of crucial importance for long-term outcomes. The present prospective study was performed to evaluate whether defect location had any influence on clinical and biomechanical outcomes 4years after ACI. Methods: Forty-four patients with full-thickness cartilage defects ICRS grade III B and C underwent ACI and were assigned to two groups, the femoral condyle group or the patellofemoral joint group. Clinical scores were gathered preoperatively and 6, 12 and 48months after implantation using the International Knee Documentation Committee (IKDC) score and the International Cartilage Repair Society (ICRS) form. Isokinetic strength measurements were performed 48months postoperatively comparing healthy and operated knee joint of each patient. Results: Clinical scores (ICRS, IKDC) showed continuous significant (p<0.05) improvement over the study period for both groups. Isokinetic muscle strength measurements showed significantly reduced maximum strength capacities for the operated knee joint compared to the healthy knee in both groups (p<0.05). Hamstring-quadriceps ratios of the operated extremity revealed a significant change in physiological muscle balancing (ratios >1.0) based on significantly impaired extensor muscle strength in the patellofemoral joint group. Conclusion: All patients showed significant strength deficits on the operated extremity 4years after ACI. Furthermore, the patellofemoral compartment in particular showed significantly worse hamstring-quadriceps ratios compared to condylar defects. Consequently, more efforts should be made to restore muscular strength especially of the quadriceps and the rehabilitation protocol should be adjusted accordingly. Level of evidence: II. Springer-Verlag Berlin Heidelberg, 2014 Autologous chondrocyte implantation nationallicence Articular cartilage defects nationallicence Biomechanics nationallicence Isokinetic strength measurements nationallicence Influence of defect location nationallicence Müller Sebastian Department of Traumatology, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland aut Hirschmüller Anja Department of Orthopaedics and Traumatology, University Hospital Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany aut Erggelet Christoph Department of Orthopaedics and Traumatology, University Hospital Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany aut Beckmann Nicholas Department of Orthopaedics and Trauma Surgery, University Hospital Heidelberg, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany aut Kreuz Peter Department of Orthopaedic Surgery, University Medical Center Rostock, Doberanerstr. 142, 18057, Rostock, Germany aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/8(2015-08-01), 2151-2158 0942-2056 23:8<2151 2015 23 167 https://doi.org/10.1007/s00167-014-2964-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-014-2964-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Müller Sebastian Department of Traumatology, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland aut NATIONALLICENCE 700 1- Hirschmüller Anja Department of Orthopaedics and Traumatology, University Hospital Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany aut NATIONALLICENCE 700 1- Erggelet Christoph Department of Orthopaedics and Traumatology, University Hospital Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany aut NATIONALLICENCE 700 1- Beckmann Nicholas Department of Orthopaedics and Trauma Surgery, University Hospital Heidelberg, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany aut NATIONALLICENCE 700 1- Kreuz Peter Department of Orthopaedic Surgery, University Medical Center Rostock, Doberanerstr. 142, 18057, Rostock, Germany aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/8(2015-08-01), 2151-2158 0942-2056 23:8<2151 2015 23 167