caa a22 4500 605459665 CHVBK 20210128100235.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00167-014-2955-z doi (NATIONALLICENCE)springer-10.1007/s00167-014-2955-z Intra-articular zoledronic acid in a rat osteoarthritis model: significant reduced synovitis may indicate chondroprotective effect [Elektronische Daten] [B. Cınar, Gurkan Ozkoc, Filiz Bolat, Oguz Karaeminogullari, Nurzen Sezgin, Reha Tandogan] Purpose: The aim of this experimental study was to evaluate the effect of intra-articular application of zoledronic acid (ZA) on joint cartilage and synovial tissue following induction of knee osteoarthritis (OA) in a rat model. Methods: An OA model was created by anterior cruciate ligament transection (ACLT) in the right knees of 48 adult Wistar albino rats. The rats were randomized into a study and control groups, each including 24 rats, and 10μg of ZA was injected in 0.1ml of sterile saline to 24 animals in the study group on the first day to operation and was repeated weekly until the rats were killed. The same volume of sterile saline was injected with the same schedule to the control group. Eight rats from both the study and control groups were killed, each time, on the 4th day, the 3rd week, and the 6th week after the operation. The groups were compared based on the histological scores of synovitis and cartilage destruction and the evaluation of serum markers. Results: Histological score indicates progression of synovitis was significantly less in the study group (p=0.047). There was significant increase in the mean Mankin cartilage damage score in the control group (p=0.021), while no significant change was found in the study group. When the two groups were compared over time, no statistically significant difference was detected in total histological scores, although there was a 47% less incidence of cartilage tissue damage in the study group and better cartilage structure and tide mark integrity scores were also detected in the study group (p=0.017 and p=0.021, respectively). Conclusion: Intra- articular zoledronic acid may suppress synovial inflammation.Furthermore, Zoledronic Acid does not reduce cartilage degeneration in earlyosteoarthritis models, but may provide some chondroprotective effect in ACLT- inducedknee osteoarthritis model in rats. Springer-Verlag Berlin Heidelberg, 2014 Zoledronic acid nationallicence Osteoarthritis nationallicence Intra-articular nationallicence Cınar B. Department of Orthopedics and Traumatology, Adana Research and Clinic Center, Baskent University School of Medicine, Dadaloglu Mah.39.Sok. No: 6, 01250, Yuregir/Adana, Turkey aut Ozkoc Gurkan Department of Orthopedics and Traumatology, Adana Research and Clinic Center, Baskent University School of Medicine, Dadaloglu Mah.39.Sok. No: 6, 01250, Yuregir/Adana, Turkey aut Bolat Filiz Department of Pathology, Baskent University School of Medicine, Adana, Turkey aut Karaeminogullari Oguz Department of Orthopedics and Traumatology, Bayındır Hospital, Ankara, Turkey aut Sezgin Nurzen Department of Biochemistiry, Baskent University School of Medicine, Adana, Turkey aut Tandogan Reha Department of Orthopedics and Traumatology, Çankaya Hospital, Adana, Turkey aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/5(2015-05-01), 1410-1418 0942-2056 23:5<1410 2015 23 167 https://doi.org/10.1007/s00167-014-2955-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-014-2955-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cınar B. Department of Orthopedics and Traumatology, Adana Research and Clinic Center, Baskent University School of Medicine, Dadaloglu Mah.39.Sok. No: 6, 01250, Yuregir/Adana, Turkey aut NATIONALLICENCE 700 1- Ozkoc Gurkan Department of Orthopedics and Traumatology, Adana Research and Clinic Center, Baskent University School of Medicine, Dadaloglu Mah.39.Sok. No: 6, 01250, Yuregir/Adana, Turkey aut NATIONALLICENCE 700 1- Bolat Filiz Department of Pathology, Baskent University School of Medicine, Adana, Turkey aut NATIONALLICENCE 700 1- Karaeminogullari Oguz Department of Orthopedics and Traumatology, Bayındır Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Sezgin Nurzen Department of Biochemistiry, Baskent University School of Medicine, Adana, Turkey aut NATIONALLICENCE 700 1- Tandogan Reha Department of Orthopedics and Traumatology, Çankaya Hospital, Adana, Turkey aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/5(2015-05-01), 1410-1418 0942-2056 23:5<1410 2015 23 167