Synovial cytokine expression in ankle osteoarthritis depends on age and stage
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| 024 | 7 | 0 | |a 10.1007/s00167-013-2719-1 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00167-013-2719-1 | ||
| 245 | 0 | 0 | |a Synovial cytokine expression in ankle osteoarthritis depends on age and stage |h [Elektronische Daten] |c [Hagen Schmal, Ralf Henkelmann, Alexander Mehlhorn, Kilian Reising, Gerrit Bode, Norbert Südkamp, Philipp Niemeyer] |
| 520 | 3 | |a Purpose: Aim of the study was the analysis of cytokine expression in ankle osteoarthritis (OA) hypothesizing age-dependent regulation patterns. Methods: Forty-nine patients undergoing an arthroscopy of the ankle with different stages of chronic OA were prospectively included in a clinical trial comparing the group <18years (n=9, Ø15.1±2.0years) with the older patients (≥18years, n=40, Ø36.5±11.9). Lavage fluids were analysed by ELISA for levels of aggrecan, BMP-2/7, IGF-1/R, bFGF, CD105, MMP-13, and IL-1β. Additionally, clinical parameters and scores (FFI, CFSS, AOFAS) were evaluated and supplemented by radiographic scores [Kellgren-Lawrence Score (KLS) for conventional X-rays, Ankle Osteoarthritis Scoring System (AOSS) for MRI]. Results: In contrast to distribution of gender and BMI (p<0.005), parameters characterizing the cartilage defect as ICRS grading, size, and duration of symptoms were not dependent on age. The incidence of osteochondritis dissecans (OCD) was higher in the group <18years (p<0.006), but the average degree of OCD grading was not different. KLS and AOSS were significantly higher in the group ≥18years (p<0.02). Correlating with the higher degree of OA in the elderly, clinical function measured by FFI and AOFAS was statistically significantly worse (p<0.05). Intra-articular concentrations of aggrecan (3.1-fold), bFGF (8.7-fold), BMP-7 (2.7-fold), and CD105 (1.5-fold) were statistically significantly higher in the group≥18years (p<0.03). Conclusions: Confirming the hypothesis, increased synovial levels of aggrecan, bFGF, BMP-7, and CD105 were found in patients over 18years. This correlated with a higher stage of OA determined by radiographic changes or deteriorated function and may offer starting points for new diagnostics and interventional strategies. Level of evidence: II. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2013 | ||
| 690 | 7 | |a Ankle |2 nationallicence | |
| 690 | 7 | |a Osteoarthritis |2 nationallicence | |
| 690 | 7 | |a Ankle Osteoarthritis Scoring System |2 nationallicence | |
| 690 | 7 | |a CD105 |2 nationallicence | |
| 690 | 7 | |a BMP-7 |2 nationallicence | |
| 690 | 7 | |a Aggrecan |2 nationallicence | |
| 690 | 7 | |a Biomarker |2 nationallicence | |
| 690 | 7 | |a bFGF |2 nationallicence | |
| 690 | 7 | |a Clinical trial |2 nationallicence | |
| 700 | 1 | |a Schmal |D Hagen |u Department of Orthopaedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, 79106, Freiburg i.Br., Germany |4 aut | |
| 700 | 1 | |a Henkelmann |D Ralf |u Department of Orthopaedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, 79106, Freiburg i.Br., Germany |4 aut | |
| 700 | 1 | |a Mehlhorn |D Alexander |u Department of Orthopaedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, 79106, Freiburg i.Br., Germany |4 aut | |
| 700 | 1 | |a Reising |D Kilian |u Department of Orthopaedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, 79106, Freiburg i.Br., Germany |4 aut | |
| 700 | 1 | |a Bode |D Gerrit |u Department of Orthopaedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, 79106, Freiburg i.Br., Germany |4 aut | |
| 700 | 1 | |a Südkamp |D Norbert |u Department of Orthopaedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, 79106, Freiburg i.Br., Germany |4 aut | |
| 700 | 1 | |a Niemeyer |D Philipp |u Department of Orthopaedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, 79106, Freiburg i.Br., Germany |4 aut | |
| 773 | 0 | |t Knee Surgery, Sports Traumatology, Arthroscopy |d Springer Berlin Heidelberg |g 23/5(2015-05-01), 1359-1367 |x 0942-2056 |q 23:5<1359 |1 2015 |2 23 |o 167 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00167-013-2719-1 |q text/html |z Onlinezugriff via DOI |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00167-013-2719-1 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Schmal |D Hagen |u Department of Orthopaedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, 79106, Freiburg i.Br., Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Henkelmann |D Ralf |u Department of Orthopaedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, 79106, Freiburg i.Br., Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mehlhorn |D Alexander |u Department of Orthopaedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, 79106, Freiburg i.Br., Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Reising |D Kilian |u Department of Orthopaedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, 79106, Freiburg i.Br., Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bode |D Gerrit |u Department of Orthopaedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, 79106, Freiburg i.Br., Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Südkamp |D Norbert |u Department of Orthopaedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, 79106, Freiburg i.Br., Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Niemeyer |D Philipp |u Department of Orthopaedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, 79106, Freiburg i.Br., Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Knee Surgery, Sports Traumatology, Arthroscopy |d Springer Berlin Heidelberg |g 23/5(2015-05-01), 1359-1367 |x 0942-2056 |q 23:5<1359 |1 2015 |2 23 |o 167 | ||