caa a22 4500 605459762 CHVBK 20210128100235.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00167-013-2807-2 doi (NATIONALLICENCE)springer-10.1007/s00167-013-2807-2 Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis [Elektronische Daten] [Yong-Gon Koh, Yun-Jin Choi, Sae-Kwang Kwon, Yong-Sang Kim, Jee-Eun Yeo] Purpose: In the present study, the clinical outcomes and second-look arthroscopic findings of intra-articular injection of stem cells with arthroscopic lavage for treatment of elderly patients with knee osteoarthritis (OA) were evaluated. Methods: Stem cell injections combined with arthroscopic lavage were administered to 30 elderly patients (≥65years) with knee OA. Subcutaneous adipose tissue was harvested from both buttocks by liposuction. After stromal vascular fractions were isolated, a mean of 4.04×106 stem cells (9.7% of 4.16×107 stromal vascular fraction cells) were prepared and injected in the selected knees of patients after arthroscopic lavage. Outcome measures included the Knee Injury and Osteoarthritis Outcome Scores, visual analog scale, and Lysholm score at preoperative and 3-, 12-, and 2-year follow-up visits. Sixteen patients underwent second-look arthroscopy. Results: Almost all patients showed significant improvement in all clinical outcomes at the final follow-up examination. All clinical results significantly improved at 2-year follow-up compared to 12-month follow-up (P<0.05). Among elderly patients aged >65years, only five patients demonstrated worsening of Kellgren-Lawrence grade. On second-look arthroscopy, 87.5% of elderly patients (14/16) improved or maintained cartilage status at least 2years postoperatively. Moreover, none of the patients underwent total knee arthroplasty during this 2-year period. Conclusion: Adipose-derived stem cell therapy for elderly patients with knee OA was effective in cartilage healing, reducing pain, and improving function. Therefore, adipose-derived stem cell treatment appears to be a good option for OA treatment in elderly patients. Level of evidence: Therapeutic case series study, Level IV. Springer-Verlag Berlin Heidelberg, 2013 Mesenchymal stem cell nationallicence Arthroscopic lavage nationallicence Knee osteoarthritis nationallicence Koh Yong-Gon Center for Stem Cell and Arthritis Research, Department of Orthopedic Surgery, Yonsei Sarang Hospital, 478-3, Bangbae-dong, Seocho-gu, Seoul, South Korea aut Choi Yun-Jin Center for Stem Cell and Arthritis Research, Department of Orthopedic Surgery, Yonsei Sarang Hospital, 478-3, Bangbae-dong, Seocho-gu, Seoul, South Korea aut Kwon Sae-Kwang Center for Stem Cell and Arthritis Research, Department of Orthopedic Surgery, Yonsei Sarang Hospital, 478-3, Bangbae-dong, Seocho-gu, Seoul, South Korea aut Kim Yong-Sang Center for Stem Cell and Arthritis Research, Department of Orthopedic Surgery, Yonsei Sarang Hospital, 478-3, Bangbae-dong, Seocho-gu, Seoul, South Korea aut Yeo Jee-Eun Center for Stem Cell and Arthritis Research, Department of Orthopedic Surgery, Yonsei Sarang Hospital, 478-3, Bangbae-dong, Seocho-gu, Seoul, South Korea aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/5(2015-05-01), 1308-1316 0942-2056 23:5<1308 2015 23 167 https://doi.org/10.1007/s00167-013-2807-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-013-2807-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koh Yong-Gon Center for Stem Cell and Arthritis Research, Department of Orthopedic Surgery, Yonsei Sarang Hospital, 478-3, Bangbae-dong, Seocho-gu, Seoul, South Korea aut NATIONALLICENCE 700 1- Choi Yun-Jin Center for Stem Cell and Arthritis Research, Department of Orthopedic Surgery, Yonsei Sarang Hospital, 478-3, Bangbae-dong, Seocho-gu, Seoul, South Korea aut NATIONALLICENCE 700 1- Kwon Sae-Kwang Center for Stem Cell and Arthritis Research, Department of Orthopedic Surgery, Yonsei Sarang Hospital, 478-3, Bangbae-dong, Seocho-gu, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Yong-Sang Center for Stem Cell and Arthritis Research, Department of Orthopedic Surgery, Yonsei Sarang Hospital, 478-3, Bangbae-dong, Seocho-gu, Seoul, South Korea aut NATIONALLICENCE 700 1- Yeo Jee-Eun Center for Stem Cell and Arthritis Research, Department of Orthopedic Surgery, Yonsei Sarang Hospital, 478-3, Bangbae-dong, Seocho-gu, Seoul, South Korea aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/5(2015-05-01), 1308-1316 0942-2056 23:5<1308 2015 23 167