Effect of VEGF-A165 addition on the integration of a cortical allograft in a tibial segmental defect in rabbits
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| 024 | 7 | 0 | |a 10.1007/s00167-013-2785-4 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00167-013-2785-4 | ||
| 245 | 0 | 0 | |a Effect of VEGF-A165 addition on the integration of a cortical allograft in a tibial segmental defect in rabbits |h [Elektronische Daten] |c [Miguel Ruiz-Ibán, Fausto Gonzalez-Lizán, Jorge Diaz-Heredia, Maria Elías-Martin, Carlos Correa Gorospe] |
| 520 | 3 | |a Purpose: Long-bone segmental defects caused by infection, fracture, or tumour are a challenge for orthopaedic surgeons. Structural allografts are sometimes used in their treatment but their poor biological characteristics are a liability. The objective of this study was to determine whether the addition of recombinant vascular endothelial growth factor-A (VEGF) to a structural allograft improved its integration into a rabbit tibial segmental defect in a non-union model. Methods: Tibial segmental defects were filled with heat sterilized allogenic tubular tibiae sections and then stabilized with a screw plate. In the VEGF treatment group (n=6 tibiae), 2μg of VEGF added to a 50μl matrigel solution was inserted into the allograft cavity. In the control group (n=6 tibiae), only matrigel was added. After 12weeks, macroscopic and microscopic analysis, radiographs, and computerized micro-tomography (micro-CT) were performed. If allograft consolidation was present, a torsional resistance analysis was performed. Results: Addition of VEGF to the allograft decreased the rate of osteosynthesis failure compared with the control group (1/6 vs. 5/6, p=0.08), increased trabecular continuity evaluated by micro-CT in the bone-allograft interphases (8/12 vs. 2/12, p=0.036) and histological trabecular continuity (7/12 vs. 0/12, p=0.0046). Full consolidation was observed in three tibiae of the VEGF group and one in the control group (differences not significant); however, torsional resistance showed no significant differences (n.s.). Conclusion: Addition of VEGF to a structural allograph inserted into a rabbit tibial segmental defect increased allograft integration rate. Further research in this direction might help clinicians in dealing with large bone defects. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2013 | ||
| 690 | 7 | |a Tibia |2 nationallicence | |
| 690 | 7 | |a Allograft |2 nationallicence | |
| 690 | 7 | |a Non-union |2 nationallicence | |
| 690 | 7 | |a Rabbit |2 nationallicence | |
| 690 | 7 | |a VEGF |2 nationallicence | |
| 700 | 1 | |a Ruiz-Ibán |D Miguel |u Department of Orthopaedic Surgery and Trauma, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain |4 aut | |
| 700 | 1 | |a Gonzalez-Lizán |D Fausto |u Department of Orthopaedic Surgery and Trauma, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain |4 aut | |
| 700 | 1 | |a Diaz-Heredia |D Jorge |u Department of Orthopaedic Surgery and Trauma, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain |4 aut | |
| 700 | 1 | |a Elías-Martin |D Maria |u Department of Anesthesiology and Reanimation, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain |4 aut | |
| 700 | 1 | |a Correa Gorospe |D Carlos |u Experimental Surgery Unit, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain |4 aut | |
| 773 | 0 | |t Knee Surgery, Sports Traumatology, Arthroscopy |d Springer Berlin Heidelberg |g 23/5(2015-05-01), 1393-1400 |x 0942-2056 |q 23:5<1393 |1 2015 |2 23 |o 167 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00167-013-2785-4 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00167-013-2785-4 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ruiz-Ibán |D Miguel |u Department of Orthopaedic Surgery and Trauma, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gonzalez-Lizán |D Fausto |u Department of Orthopaedic Surgery and Trauma, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Diaz-Heredia |D Jorge |u Department of Orthopaedic Surgery and Trauma, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Elías-Martin |D Maria |u Department of Anesthesiology and Reanimation, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Correa Gorospe |D Carlos |u Experimental Surgery Unit, Hospital Universitario Ramón y Cajal, Cta Colmenar Km 9.100, 28034, Madrid, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Knee Surgery, Sports Traumatology, Arthroscopy |d Springer Berlin Heidelberg |g 23/5(2015-05-01), 1393-1400 |x 0942-2056 |q 23:5<1393 |1 2015 |2 23 |o 167 | ||