caa a22 4500 605459878 CHVBK 20210128100236.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00167-013-2734-2 doi (NATIONALLICENCE)springer-10.1007/s00167-013-2734-2 The biomechanical and histological effects of platelet-rich plasma on fracture healing [Elektronische Daten] [Yunus Guzel, Nazım Karalezli, Onur Bilge, Burkay Kacira, Hasan Esen, Hakan Karadag, Serdar Toker, Recep Göncü, Mahmut Doral] Purpose: Platelet-rich plasma (PRP) includes growth factors and proteins that accelerate and stimulate bone regeneration and tissue recovery. The aim of this study was to evaluate the effects of PRP on fracture healing in terms of biomechanics and histology. Methods: Seventy female rats were included in this experimental study. They were divided into three groups: Group I (no PRP, n=30), Group II (PRP added, n=30) and Group III (control, n=10). The left femurs of the rats in Groups I and II were osteotomized and fixed by K-wires. Although no additional intervention was performed on Group I rats, PRP was applied to the fracture sites of Group II rats. The remaining ten rats were used as the control group of the biomechanical test (Group III). In the fourth week, nine femurs from Group I and ten femurs from Group II, and in the ninth week, nine femurs from each group were removed, and bone recovery was assessed histologically according to Modified Lane-Sandhu histological scoring criteria. Three-point bending test was applied to femurs for biomechanical evaluation in the ninth week. Results: Histological healing was found to be significantly higher in Group II than in Group I (p<0.05). Furthermore, biomechanical test results showed that healing quantity and bone strength were significantly better in Group II than in Group I (p<0.05). Conclusion: PRP is a widely studied material in the physiology of fracture healing. The results of this study demonstrated the ameliorative biomechanical effects of PRP on fracture healing, in addition to accelerating the histological union of fractures. In the light of these results, PRP could be a viable alternative to accelerate the healing of fractures, late unions or non-unions. Level of evidence: Prospective comparative study, Level II. Springer-Verlag Berlin Heidelberg, 2013 Platelet-rich plasma (PRP) nationallicence PRGF nationallicence Fracture nationallicence Union nationallicence Biomechanics nationallicence Guzel Yunus Department of Orthopaedics and Traumatology, Faculty of Medicine, Ordu University, Ordu, Turkey aut Karalezli Nazım Department of Orthopaedics and Traumatology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey aut Bilge Onur Department of Orthopaedics and Traumatology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey aut Kacira Burkay Department of Orthopaedics and Traumatology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey aut Esen Hasan Department of Pathology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey aut Karadag Hakan Department of Mechanical Engineering, Faculty of Mechanical Engineering, Necmettin Erbakan University, Konya, Turkey aut Toker Serdar Department of Orthopaedics and Traumatology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey aut Göncü Recep Department of Orthopaedics and Traumatology, Government Hospital of Beyhekim, Konya, Turkey aut Doral Mahmut Department of Orthopaedics and Traumatology, Hacettepe Faculty of Medicine, Hacettepe University, Ankara, Turkey aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/5(2015-05-01), 1378-1383 0942-2056 23:5<1378 2015 23 167 https://doi.org/10.1007/s00167-013-2734-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-013-2734-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Guzel Yunus Department of Orthopaedics and Traumatology, Faculty of Medicine, Ordu University, Ordu, Turkey aut NATIONALLICENCE 700 1- Karalezli Nazım Department of Orthopaedics and Traumatology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey aut NATIONALLICENCE 700 1- Bilge Onur Department of Orthopaedics and Traumatology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey aut NATIONALLICENCE 700 1- Kacira Burkay Department of Orthopaedics and Traumatology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey aut NATIONALLICENCE 700 1- Esen Hasan Department of Pathology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey aut NATIONALLICENCE 700 1- Karadag Hakan Department of Mechanical Engineering, Faculty of Mechanical Engineering, Necmettin Erbakan University, Konya, Turkey aut NATIONALLICENCE 700 1- Toker Serdar Department of Orthopaedics and Traumatology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey aut NATIONALLICENCE 700 1- Göncü Recep Department of Orthopaedics and Traumatology, Government Hospital of Beyhekim, Konya, Turkey aut NATIONALLICENCE 700 1- Doral Mahmut Department of Orthopaedics and Traumatology, Hacettepe Faculty of Medicine, Hacettepe University, Ankara, Turkey aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/5(2015-05-01), 1378-1383 0942-2056 23:5<1378 2015 23 167