caa a22 4500 605459894 CHVBK 20210128100236.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00167-014-2853-4 doi (NATIONALLICENCE)springer-10.1007/s00167-014-2853-4 Bone substitutes and implantation depths for subchondral bone repair in osteochondral defects of porcine knee joints [Elektronische Daten] [Tomohiko Matsuo, Keisuke Kita, Tatsuo Mae, Yasukazu Yonetani, Satoshi Miyamoto, Hideki Yoshikawa, Ken Nakata] Purpose: The purpose of this study was to identify the optimal material and implantation method for subchondral bone repair. Methods: Four osteochondral defects in a femoral groove were created in both knees of 12 pigs, and the total number of defects was 96. Eight defects were left empty (empty group). Beta-tricalcium phosphate (β-TCP) bone substitutes with 75 and 67% porosity were implanted in 30 and 29 defects, respectively (β-TCP75 and β-TCP67 groups). Hydroxyapatite (HA) bone substitutes with 75% porosity were filled in 29 defects (HA group). Bone substitutes were implanted at 0, 2, or 4mm below the subchondral bone plate (SBP). The reparative tissue was assessed using microfocus computed tomography and histology 3months after implantation. Results: Regardless of the kind of bone substitutes, the defects were filled almost completely after implanting them at the level of the SBP, while the defects remained after implanting them at 2 or 4mm below the SBP. Reparative tissue of the β-TCP75 group was similar to the normal cancellous bone, while that of the β-TCP67 or HA group was not. Conclusions: Subchondral bone defects were filled almost completely only when bone substitutes were implanted at the level of the SBP. The reparative tissue after implanting the β-TCP bone substitutes with 75% porosity was the most similar to the normal cancellous bone. Therefore, implanting the β-TCP bone substitutes with 75% porosity at the level of the SBP could be recommended as a treatment method for subchondral bone repair in osteochondral defects. Level of evidence: I. Springer-Verlag Berlin Heidelberg, 2014 Subchondral bone osteochondral defect nationallicence Bone substitute nationallicence Hydroxyapatite nationallicence Beta-tricalcium phosphate nationallicence Matsuo Tomohiko Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan aut Kita Keisuke Department of Sports Orthopaedics, Osaka Rosai Hospital, 1179-3, Nagasone-cho, Kita-ku, 583-8555, Sakai, Osaka, Japan aut Mae Tatsuo Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan aut Yonetani Yasukazu Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan aut Miyamoto Satoshi Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan aut Yoshikawa Hideki Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan aut Nakata Ken Medicine for Sports and Performing Arts, Department of Health and Sports Sciences, Osaka University Graduate School of Medicine, 1-17 Machikaneyama-cho, 560-0043, Toyonaka, Osaka, Japan aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/5(2015-05-01), 1401-1409 0942-2056 23:5<1401 2015 23 167 https://doi.org/10.1007/s00167-014-2853-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-014-2853-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Matsuo Tomohiko Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kita Keisuke Department of Sports Orthopaedics, Osaka Rosai Hospital, 1179-3, Nagasone-cho, Kita-ku, 583-8555, Sakai, Osaka, Japan aut NATIONALLICENCE 700 1- Mae Tatsuo Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Yonetani Yasukazu Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Miyamoto Satoshi Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Yoshikawa Hideki Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Nakata Ken Medicine for Sports and Performing Arts, Department of Health and Sports Sciences, Osaka University Graduate School of Medicine, 1-17 Machikaneyama-cho, 560-0043, Toyonaka, Osaka, Japan aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/5(2015-05-01), 1401-1409 0942-2056 23:5<1401 2015 23 167