caa a22 4500 605460477 CHVBK 20210128100238.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00167-014-3153-8 doi (NATIONALLICENCE)springer-10.1007/s00167-014-3153-8 Does a thrombin-based topical haemostatic agent reduce blood loss and transfusion requirements after total knee revision surgery? A randomized, controlled trial [Elektronische Daten] [Carlo Romanò, Lorenzo Monti, Nicola Logoluso, Delia Romanò, Lorenzo Drago] Purpose: The aim of the present study was to assess the efficacy of a thrombin-based topical haemostatic in reducing blood requirements after total knee replacement (TKR) revision surgery. Methods: This prospective, randomized, controlled study was designed to evaluate the haemostatic efficacy and safety of a thrombin-based topical haemostatic (Floseal) versus standard treatment in patients receiving total knee revision arthroplasty. The decrease in haemoglobin values postsurgery and the blood units transfused were recorded. The decision to transfuse was made by a surgeon blinded to the patient's group allocation. Results: Forty-eight patients were enroled in the study; twenty-four patients each were randomized to the treatment and control groups, respectively. The median decrease in haemoglobin concentration on the first postoperative day was 2.2g/dL in the treatment group and 2.7g/dL in the control group. A significant reduction in units of blood transfused was also observed in the treatment group compared with the control group [1.1±1.13 (range 0-4) vs. 1.9±1.41 (range 0-5) blood units; P=0.04]. No major treatment-related adverse events were recorded in the study. Conclusions: This study shows that a thrombin-based topical haemostatic reduces the need for blood transfusion in TKR revision surgery. Clinical relevance: A thrombin-based topical haemostatic agent can be an appropriate solution to enhance haemostasis and vessel sealing at the operative site in TKR revision surgery, in order to reduce the need for blood transfusion after surgery. Level of evidence: II. Springer-Verlag Berlin Heidelberg, 2014 Floseal nationallicence Revision arthroplasty nationallicence Thrombin-based topical haemostatic nationallicence Total knee replacement nationallicence Transfusion nationallicence Romanò Carlo Department of Bone and Joint Infections and Reconstructive Surgery, IRCCS Orthopaedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy aut Monti Lorenzo Department of Bone and Joint Infections and Reconstructive Surgery, IRCCS Orthopaedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy aut Logoluso Nicola Department of Bone and Joint Infections and Reconstructive Surgery, IRCCS Orthopaedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy aut Romanò Delia Department of Bone and Joint Infections and Reconstructive Surgery, IRCCS Orthopaedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy aut Drago Lorenzo Laboratory of Clinical Chemistry and Microbiology, IRCCS Orthopedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/11(2015-11-01), 3337-3342 0942-2056 23:11<3337 2015 23 167 https://doi.org/10.1007/s00167-014-3153-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-014-3153-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Romanò Carlo Department of Bone and Joint Infections and Reconstructive Surgery, IRCCS Orthopaedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy aut NATIONALLICENCE 700 1- Monti Lorenzo Department of Bone and Joint Infections and Reconstructive Surgery, IRCCS Orthopaedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy aut NATIONALLICENCE 700 1- Logoluso Nicola Department of Bone and Joint Infections and Reconstructive Surgery, IRCCS Orthopaedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy aut NATIONALLICENCE 700 1- Romanò Delia Department of Bone and Joint Infections and Reconstructive Surgery, IRCCS Orthopaedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy aut NATIONALLICENCE 700 1- Drago Lorenzo Laboratory of Clinical Chemistry and Microbiology, IRCCS Orthopedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/11(2015-11-01), 3337-3342 0942-2056 23:11<3337 2015 23 167