caa a22 4500 605460531 CHVBK 20210128100239.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00167-014-3155-6 doi (NATIONALLICENCE)springer-10.1007/s00167-014-3155-6 MRI evaluation of a collagen meniscus implant: a systematic review [Elektronische Daten] [Stefano Zaffagnini, Alberto Grassi, Giulio Marcheggiani Muccioli, Tommaso Bonanzinga, Marco Nitri, Federico Raggi, Giovanni Ravazzolo, Maurilio Marcacci] Purpose: Good clinical results have been demonstrated in numerous clinical studies using the collagen meniscus implant (CMI); however, the MRI behaviour of the scaffold, evaluated with Genovese score, is limited to a few cases series. The purpose was to evaluate, using the Genovese score, the MRI behaviour of the CMI at different follow-up periods and investigate possible differences in the behaviour of lateral and medial CMI. Methods: A comprehensive search was performed on PubMed, Medline, CINAHL, Cochrane, Embase and Google Scholar databases using various combinations of the following keywords: "collagen meniscus implant” or "collagen meniscal implant”. All the studies evaluating medial or lateral CMI using Genovese score for MRI were included in the systematic review. Results: Six studies have been included in the systematic review, with no RCT's. The pooled number of patients involved in CMI surgery was 194 (83% medial and 17% lateral), with a mean age at surgery of 37.7years. Concomitant procedures raged from 11 to 52%. CMI morphology was grade 1 in 0, 2.7, 5.9, 0, 16.7%, respectively, at 6months, 1, 2, 5, 10years. It was grade 2 in 12.5, 60.9, 60.3, 74.4, 75%, respectively, at 6months, 1, 2, 5, 10years and grade 3 in 87.5, 36.4, 33.8, 25.6, 8.3% at the same time points. CMI signal intensity was grade 1 in 80, 18.2, 25, 11.1, 22.2%, respectively, at 6months, 1, 2, 5, 10years. It was grade 2 in 20, 78.2, 54.7, 55.6, 66.7%, respectively, at 6months, 1, 2, 5, 10years and grade 3 in 0, 3.6, 20.3, 33.3, 11.1% at the same time points. Slight differences were found between medial and lateral CMI in size and signal intensity. Conclusions: Higher rates of scaffolds with reduced size and with an MRI signal intensity more similar to normal meniscus were reported at longer follow-up compared with initial evaluations. Correlation between MRI findings and gross CMI appearance has not been reported. Level of evidence: IV. Springer-Verlag Berlin Heidelberg, 2014 Collagen meniscus implant nationallicence Magnetic resonance nationallicence Scaffold nationallicence Biologic nationallicence Zaffagnini Stefano Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut Grassi Alberto Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut Marcheggiani Muccioli Giulio Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut Bonanzinga Tommaso Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut Nitri Marco Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut Raggi Federico Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut Ravazzolo Giovanni Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut Marcacci Maurilio Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/11(2015-11-01), 3228-3237 0942-2056 23:11<3228 2015 23 167 https://doi.org/10.1007/s00167-014-3155-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00167-014-3155-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zaffagnini Stefano Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut NATIONALLICENCE 700 1- Grassi Alberto Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut NATIONALLICENCE 700 1- Marcheggiani Muccioli Giulio Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut NATIONALLICENCE 700 1- Bonanzinga Tommaso Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut NATIONALLICENCE 700 1- Nitri Marco Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut NATIONALLICENCE 700 1- Raggi Federico Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut NATIONALLICENCE 700 1- Ravazzolo Giovanni Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut NATIONALLICENCE 700 1- Marcacci Maurilio Clinica Ortopedica e Traumatologica II - Lab. di Biomeccanica, ed Innovazione Tecnologica, Istituto Ortopedico Rizzoli, Bologna, Italy aut NATIONALLICENCE 773 0- Knee Surgery, Sports Traumatology, Arthroscopy Springer Berlin Heidelberg 23/11(2015-11-01), 3228-3237 0942-2056 23:11<3228 2015 23 167