Prospective, mono-institutional study of the impact of a systematic prevention program on incidence and outcome of osteonecrosis of the jaw in patients treated with bisphosphonates for bone metastases
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| 024 | 7 | 0 | |a 10.1007/s00774-014-0566-x |2 doi |
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| 245 | 0 | 0 | |a Prospective, mono-institutional study of the impact of a systematic prevention program on incidence and outcome of osteonecrosis of the jaw in patients treated with bisphosphonates for bone metastases |h [Elektronische Daten] |c [Annalisa Bramati, Serena Girelli, Gabriella Farina, Maria Dazzani, Valter Torri, Anna Moretti, Sheila Piva, Mariastella Dimaiuta, Nicla La Verde] |
| 520 | 3 | |a The aim of our study was to investigate the occurrence of osteonecrosis of the jaw (ONJ) after implementation of dental preventive measures before starting bisphosphonates (BPs) therapy and during treatment. All consecutive patients with bone lesions eligible for BPs treatment were prospectively evaluated. Before starting BPs, each patient underwent a strict dental preventive program with a specialized odontoiatric team. The odontoiatric evaluation identified patients with oral pathologies or inadequate oral hygiene and provided a dental preventive treatment. From April 2007 to April 2012, 254 patients were enrolled. After excluding patients due to previous BPs treatment, 212 patients with a mean age of 74years (range 37-95) were included. On average, patients received 9.7 treatment cycles (range 1-48). No ONJ was recorded (0.0%; 95% confidence interval [CI] 0.0-1.4). Comparing this risk with that observed in a previous cohort who did not receive dental prevention (16/186, 8.6%; 95% CI 4.2-15.3%), we observed clear efficacy in preventing ONJ (relative risk reduction: 100%, 95% CI 86-100%, P<0.0001). We developed a strict three-step prevention program that is able to decrease ONJ incidence and the need for destructive surgery with permanent sequelae. We demonstrated that ONJ could be effectively prevented. We recommend a mandatory preventive program involving a multidisciplinary team for all patients starting BPs. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 | ||
| 690 | 7 | |a Bisphosphonates |2 nationallicence | |
| 690 | 7 | |a Bone metastases |2 nationallicence | |
| 690 | 7 | |a Oral preventive program |2 nationallicence | |
| 690 | 7 | |a Osteonecrosis of the jaw (ONJ) |2 nationallicence | |
| 700 | 1 | |a Bramati |D Annalisa |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | |
| 700 | 1 | |a Girelli |D Serena |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | |
| 700 | 1 | |a Farina |D Gabriella |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | |
| 700 | 1 | |a Dazzani |D Maria |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | |
| 700 | 1 | |a Torri |D Valter |u Laboratory of Methodology for Biomedical Research, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri”, via La Masa 19, 20156, Milan, Italy |4 aut | |
| 700 | 1 | |a Moretti |D Anna |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | |
| 700 | 1 | |a Piva |D Sheila |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | |
| 700 | 1 | |a Dimaiuta |D Mariastella |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | |
| 700 | 1 | |a La Verde |D Nicla |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/1(2015-01-01), 119-124 |x 0914-8779 |q 33:1<119 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-014-0566-x |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-014-0566-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bramati |D Annalisa |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Girelli |D Serena |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Farina |D Gabriella |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dazzani |D Maria |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Torri |D Valter |u Laboratory of Methodology for Biomedical Research, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri”, via La Masa 19, 20156, Milan, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Moretti |D Anna |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Piva |D Sheila |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dimaiuta |D Mariastella |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a La Verde |D Nicla |u Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/1(2015-01-01), 119-124 |x 0914-8779 |q 33:1<119 |1 2015 |2 33 |o 774 | ||