caa a22 4500 605462852 CHVBK 20210128100250.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00774-014-0566-x doi (NATIONALLICENCE)springer-10.1007/s00774-014-0566-x Prospective, mono-institutional study of the impact of a systematic prevention program on incidence and outcome of osteonecrosis of the jaw in patients treated with bisphosphonates for bone metastases [Elektronische Daten] [Annalisa Bramati, Serena Girelli, Gabriella Farina, Maria Dazzani, Valter Torri, Anna Moretti, Sheila Piva, Mariastella Dimaiuta, Nicla La Verde] The aim of our study was to investigate the occurrence of osteonecrosis of the jaw (ONJ) after implementation of dental preventive measures before starting bisphosphonates (BPs) therapy and during treatment. All consecutive patients with bone lesions eligible for BPs treatment were prospectively evaluated. Before starting BPs, each patient underwent a strict dental preventive program with a specialized odontoiatric team. The odontoiatric evaluation identified patients with oral pathologies or inadequate oral hygiene and provided a dental preventive treatment. From April 2007 to April 2012, 254 patients were enrolled. After excluding patients due to previous BPs treatment, 212 patients with a mean age of 74years (range 37-95) were included. On average, patients received 9.7 treatment cycles (range 1-48). No ONJ was recorded (0.0%; 95% confidence interval [CI] 0.0-1.4). Comparing this risk with that observed in a previous cohort who did not receive dental prevention (16/186, 8.6%; 95% CI 4.2-15.3%), we observed clear efficacy in preventing ONJ (relative risk reduction: 100%, 95% CI 86-100%, P<0.0001). We developed a strict three-step prevention program that is able to decrease ONJ incidence and the need for destructive surgery with permanent sequelae. We demonstrated that ONJ could be effectively prevented. We recommend a mandatory preventive program involving a multidisciplinary team for all patients starting BPs. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Bisphosphonates nationallicence Bone metastases nationallicence Oral preventive program nationallicence Osteonecrosis of the jaw (ONJ) nationallicence Bramati Annalisa Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut Girelli Serena Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut Farina Gabriella Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut Dazzani Maria Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut Torri Valter Laboratory of Methodology for Biomedical Research, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri”, via La Masa 19, 20156, Milan, Italy aut Moretti Anna Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut Piva Sheila Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut Dimaiuta Mariastella Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut La Verde Nicla Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut Journal of Bone and Mineral Metabolism Springer Japan 33/1(2015-01-01), 119-124 0914-8779 33:1<119 2015 33 774 https://doi.org/10.1007/s00774-014-0566-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0566-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bramati Annalisa Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut NATIONALLICENCE 700 1- Girelli Serena Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut NATIONALLICENCE 700 1- Farina Gabriella Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut NATIONALLICENCE 700 1- Dazzani Maria Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut NATIONALLICENCE 700 1- Torri Valter Laboratory of Methodology for Biomedical Research, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri”, via La Masa 19, 20156, Milan, Italy aut NATIONALLICENCE 700 1- Moretti Anna Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut NATIONALLICENCE 700 1- Piva Sheila Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut NATIONALLICENCE 700 1- Dimaiuta Mariastella Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut NATIONALLICENCE 700 1- La Verde Nicla Department of Oncology, A.O. Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121, Milan, Italy aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/1(2015-01-01), 119-124 0914-8779 33:1<119 2015 33 774