Effects of manganese deficiency on chondrocyte development in tibia growth plate of Arbor Acres chicks
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| 024 | 7 | 0 | |a 10.1007/s00774-014-0563-0 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00774-014-0563-0 | ||
| 245 | 0 | 0 | |a Effects of manganese deficiency on chondrocyte development in tibia growth plate of Arbor Acres chicks |h [Elektronische Daten] |c [Jian Wang, Zhen Wang, Zhao Wang, Ran Liu, Shao Liu, Lin Wang] |
| 520 | 3 | |a The aim of this study was to investigate the effects of manganese (Mn) deficiency on chondrocyte development in tibia growth plate. Ninety 1-day-old Arbor Acres chicks were randomly divided into three groups and fed on control diet (60mg Mn/kg diet) and manganese deficient diets (40mg Mn/kg diet, manganese deficiency group I; 8.7mg Mn/kg diet, manganese deficiency group II), respectively. The width of the proliferative zone of growth plate was measured by the microscope graticule. Chondrocyte apoptosis was estimated by TUNEL staining. Gene expression of p21 and Bcl-2, and expression of related proteins were analyzed by quantitative real time reverse transcription polymerase chain reaction and immunohistochemistry, respectively. Compared with the control group, manganese deficiency significantly decreased the proliferative zone width and Bcl-2 mRNA expression level, while significantly increased the apoptotic rates and the expression level of p21 gene in chondrocytes. The results indicate that manganese deficiency had a negative effect on chondrocyte development, which was mediated by the inhibition of chondrocyte proliferation and promotion of chondrocyte apoptosis. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 | ||
| 690 | 7 | |a Manganese deficiency |2 nationallicence | |
| 690 | 7 | |a Chondrocytes |2 nationallicence | |
| 690 | 7 | |a Proliferation |2 nationallicence | |
| 690 | 7 | |a Apoptosis |2 nationallicence | |
| 700 | 1 | |a Wang |D Jian |u College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Daizong Road No. 61, 271018, Taian, People's Republic of China |4 aut | |
| 700 | 1 | |a Wang |D Zhen |u College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Daizong Road No. 61, 271018, Taian, People's Republic of China |4 aut | |
| 700 | 1 | |a Wang |D Zhao |u College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Daizong Road No. 61, 271018, Taian, People's Republic of China |4 aut | |
| 700 | 1 | |a Liu |D Ran |u College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Daizong Road No. 61, 271018, Taian, People's Republic of China |4 aut | |
| 700 | 1 | |a Liu |D Shao |u College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Daizong Road No. 61, 271018, Taian, People's Republic of China |4 aut | |
| 700 | 1 | |a Wang |D Lin |u College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Daizong Road No. 61, 271018, Taian, People's Republic of China |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/1(2015-01-01), 23-29 |x 0914-8779 |q 33:1<23 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-014-0563-0 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-014-0563-0 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wang |D Jian |u College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Daizong Road No. 61, 271018, Taian, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wang |D Zhen |u College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Daizong Road No. 61, 271018, Taian, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wang |D Zhao |u College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Daizong Road No. 61, 271018, Taian, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liu |D Ran |u College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Daizong Road No. 61, 271018, Taian, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liu |D Shao |u College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Daizong Road No. 61, 271018, Taian, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wang |D Lin |u College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Daizong Road No. 61, 271018, Taian, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/1(2015-01-01), 23-29 |x 0914-8779 |q 33:1<23 |1 2015 |2 33 |o 774 | ||