Association of plasma GDF-9 or GDF-15 levels with bone parameters in polycystic ovary syndrome
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| 024 | 7 | 0 | |a 10.1007/s00774-013-0560-8 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00774-013-0560-8 | ||
| 245 | 0 | 0 | |a Association of plasma GDF-9 or GDF-15 levels with bone parameters in polycystic ovary syndrome |h [Elektronische Daten] |c [Zehra Berberoglu, Aynur Aktas, Yasemin Fidan, Ayse Yazici, Yalcin Aral] |
| 520 | 3 | |a We aimed to determine plasma levels of growth and differentiation factor (GDF)-9 and GDF-15, and their possible association with bone turnover parameters and bone mineral density (BMD), in patients with polycystic ovary syndrome (PCOS). Forty-two obese PCOS women aged 25-35years, 23 women with idiopathic hirsutism (IH) and 20 healthy controls matched for age and body mass index were enrolled. Anthropometric, metabolic and hormonal patterns, plasma GDF-9 and GDF-15 concentrations, bone turnover markers and BMD were measured. No significant differences were observed in bone turnover markers, BMD measurements, plasma GDF-9 and GDF-15 levels in subjects with PCOS compared with the other two groups. In the combined population of all three groups, GDF-15 concentrations were negatively correlated with osteocalcin (r=−0.317, p<0.01). Analysis of PCOS patients showed a significant correlation of GDF-15 concentrations with age and homeostasis model assessment index (r=0.319, p<0.05, and r=0.312, p<0.05, respectively). In addition, GDF-15 concentrations were negatively correlated with osteocalcin (r=−0.395, p<0.01) and positively correlated with urine deoxypyridinoline (r=0.353, p<0.05). GDF-9 did not correlate with bone markers and BMD measurements. In conclusion, plasma GDF-9 and GDF-15 levels as well as bone turnover markers and BMD measurements in subjects with PCOS (25-35years of age) were comparable with those either in subjects with IH or in healthy controls with similar anthropometric and metabolic profiles. GDF-15 might be a marker of a crossregulation between bone and energy metabolism. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 | ||
| 690 | 7 | |a Polycystic ovary syndrome |2 nationallicence | |
| 690 | 7 | |a GDF-9 |2 nationallicence | |
| 690 | 7 | |a GDF-15 |2 nationallicence | |
| 690 | 7 | |a Bone parameters |2 nationallicence | |
| 700 | 1 | |a Berberoglu |D Zehra |u Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey |4 aut | |
| 700 | 1 | |a Aktas |D Aynur |u Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey |4 aut | |
| 700 | 1 | |a Fidan |D Yasemin |u Department of Biochemistry, Ankara Education and Research Hospital, Ankara, Turkey |4 aut | |
| 700 | 1 | |a Yazici |D Ayse |u Department of Biostatistics, Baskent University Faculty of Medicine, Ankara, Turkey |4 aut | |
| 700 | 1 | |a Aral |D Yalcin |u Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/1(2015-01-01), 101-108 |x 0914-8779 |q 33:1<101 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-013-0560-8 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-013-0560-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Berberoglu |D Zehra |u Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Aktas |D Aynur |u Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fidan |D Yasemin |u Department of Biochemistry, Ankara Education and Research Hospital, Ankara, Turkey |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yazici |D Ayse |u Department of Biostatistics, Baskent University Faculty of Medicine, Ankara, Turkey |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Aral |D Yalcin |u Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/1(2015-01-01), 101-108 |x 0914-8779 |q 33:1<101 |1 2015 |2 33 |o 774 | ||