caa a22 4500 605462968 CHVBK 20210128100251.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00774-013-0560-8 doi (NATIONALLICENCE)springer-10.1007/s00774-013-0560-8 Association of plasma GDF-9 or GDF-15 levels with bone parameters in polycystic ovary syndrome [Elektronische Daten] [Zehra Berberoglu, Aynur Aktas, Yasemin Fidan, Ayse Yazici, Yalcin Aral] We aimed to determine plasma levels of growth and differentiation factor (GDF)-9 and GDF-15, and their possible association with bone turnover parameters and bone mineral density (BMD), in patients with polycystic ovary syndrome (PCOS). Forty-two obese PCOS women aged 25-35years, 23 women with idiopathic hirsutism (IH) and 20 healthy controls matched for age and body mass index were enrolled. Anthropometric, metabolic and hormonal patterns, plasma GDF-9 and GDF-15 concentrations, bone turnover markers and BMD were measured. No significant differences were observed in bone turnover markers, BMD measurements, plasma GDF-9 and GDF-15 levels in subjects with PCOS compared with the other two groups. In the combined population of all three groups, GDF-15 concentrations were negatively correlated with osteocalcin (r=−0.317, p<0.01). Analysis of PCOS patients showed a significant correlation of GDF-15 concentrations with age and homeostasis model assessment index (r=0.319, p<0.05, and r=0.312, p<0.05, respectively). In addition, GDF-15 concentrations were negatively correlated with osteocalcin (r=−0.395, p<0.01) and positively correlated with urine deoxypyridinoline (r=0.353, p<0.05). GDF-9 did not correlate with bone markers and BMD measurements. In conclusion, plasma GDF-9 and GDF-15 levels as well as bone turnover markers and BMD measurements in subjects with PCOS (25-35years of age) were comparable with those either in subjects with IH or in healthy controls with similar anthropometric and metabolic profiles. GDF-15 might be a marker of a crossregulation between bone and energy metabolism. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Polycystic ovary syndrome nationallicence GDF-9 nationallicence GDF-15 nationallicence Bone parameters nationallicence Berberoglu Zehra Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey aut Aktas Aynur Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey aut Fidan Yasemin Department of Biochemistry, Ankara Education and Research Hospital, Ankara, Turkey aut Yazici Ayse Department of Biostatistics, Baskent University Faculty of Medicine, Ankara, Turkey aut Aral Yalcin Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey aut Journal of Bone and Mineral Metabolism Springer Japan 33/1(2015-01-01), 101-108 0914-8779 33:1<101 2015 33 774 https://doi.org/10.1007/s00774-013-0560-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-013-0560-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berberoglu Zehra Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey aut NATIONALLICENCE 700 1- Aktas Aynur Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey aut NATIONALLICENCE 700 1- Fidan Yasemin Department of Biochemistry, Ankara Education and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Yazici Ayse Department of Biostatistics, Baskent University Faculty of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Aral Yalcin Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/1(2015-01-01), 101-108 0914-8779 33:1<101 2015 33 774