Variation in the PTH2R gene is associated with age-related degenerative changes in the lumbar spine
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| 024 | 7 | 0 | |a 10.1007/s00774-013-0550-x |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00774-013-0550-x | ||
| 245 | 0 | 0 | |a Variation in the PTH2R gene is associated with age-related degenerative changes in the lumbar spine |h [Elektronische Daten] |c [Kristina Åkesson, Max Tenne, Paul Gerdhem, Holger Luthman, Fiona McGuigan] |
| 520 | 3 | |a In the elderly, degenerative changes in the lumbar spine are common, contributing to falsely elevated bone mineral density (BMD) values. The parathyroid hormone (PTH) system plays an important role in the regulation of bone turnover and we explore the hypothesis that polymorphisms (SNPs) within genes in this pathway (PTH, PTHLH, PTH1R and PTH2R) contribute to degenerative manifestations of the spine in elderly women. The study included 1,004 Swedish women aged 75years from the population-based OPRA cohort who attended follow-up at 5 and 10years. Lumbar spine BMD was assessed by dual energy X-ray absorptiometry (DXA) and each individual vertebra was evaluated visually on the DXA image for apparent degenerative manifestations. Six SNPs in PTH and 3 SNPs each in PTH1R, PTH2R and PTHLH were analysed. Among women with degenerative manifestations at the lumbar spine, there was an over-representation at baseline of those carrying the PTH2R SNP rs897083 A-allele (p=0.0021; odds ratio 1.5 95% CI 1.2-2.0) and across the duration of follow-up (p=0.0008). No association was observed between degenerative manifestations and variation in the other genes. None of the PTH hormone system genes were associated with vertebral fracture. Variation in the PTH2R gene (Chr2q34, rs897083) may contribute to the age-associated degenerative manifestations that develop at the lumbar spine. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2013 | ||
| 690 | 7 | |a Genetic |2 nationallicence | |
| 690 | 7 | |a Polymorphism |2 nationallicence | |
| 690 | 7 | |a PTH2R |2 nationallicence | |
| 690 | 7 | |a Degenerative changes |2 nationallicence | |
| 690 | 7 | |a Spine |2 nationallicence | |
| 700 | 1 | |a Åkesson |D Kristina |u Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmö, Lund University, SE 205 02, Malmö, Sweden |4 aut | |
| 700 | 1 | |a Tenne |D Max |u Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmö, Lund University, SE 205 02, Malmö, Sweden |4 aut | |
| 700 | 1 | |a Gerdhem |D Paul |u Department of Orthopaedics, Karolinska University Hospital, Stockholm, Sweden |4 aut | |
| 700 | 1 | |a Luthman |D Holger |u Medical Genetics Unit, Department of Clinical Sciences Malmö, Lund University, SE 205 02, Malmö, Sweden |4 aut | |
| 700 | 1 | |a McGuigan |D Fiona |u Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmö, Lund University, SE 205 02, Malmö, Sweden |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/1(2015-01-01), 9-15 |x 0914-8779 |q 33:1<9 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-013-0550-x |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-013-0550-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Åkesson |D Kristina |u Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmö, Lund University, SE 205 02, Malmö, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tenne |D Max |u Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmö, Lund University, SE 205 02, Malmö, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gerdhem |D Paul |u Department of Orthopaedics, Karolinska University Hospital, Stockholm, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Luthman |D Holger |u Medical Genetics Unit, Department of Clinical Sciences Malmö, Lund University, SE 205 02, Malmö, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a McGuigan |D Fiona |u Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmö, Lund University, SE 205 02, Malmö, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/1(2015-01-01), 9-15 |x 0914-8779 |q 33:1<9 |1 2015 |2 33 |o 774 | ||