caa a22 4500 605462992 CHVBK 20210128100251.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00774-014-0624-4 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0624-4 The impact of LRP5 polymorphism (rs556442) on calcium homeostasis, bone mineral density, and body composition in Iranian children [Elektronische Daten] [Elham Ashouri, Elham Meimandi, Forough Saki, Mohammad Dabbaghmanesh, Gholamhossein Omrani, Marzieh Bakhshayeshkaram] Failure to achieve optimal bone mass in childhood is the primary cause of decreased adult bone mineral density (BMD) and increased bone fragility in later life. Activating and inactivating LRP5 gene mutations has been associated with extreme bone-related phenotypes. Our aim was to investigate the role of LRP5 polymorphism on BMD, mineral biochemical parameters, and body composition in Iranian children. This cross-sectional study was performed on 9-18years old children (125 boys, 137 girls). The serum level of calcium, phosphorous, alkaline phosphatase, and vitamin D parameters were checked. The body composition and BMD variables were measured by the Hologic system DXA. The rs566442 (V1119V) coding polymorphism in exon 15 of LRP5 was performed using PCR-RFLP method. Linear regression analysis, with adjustment for age, gender, body size parameters, and pubertal status was used to determine the association between LRP5 polymorphism (rs556442) and bone and body composition parameters. The allele frequency of the rs566442 gene was 35.5% A and 63.9% G. Our study revealed that LRP5 (rs556442) has not any significant influence on serum calcium, phosphorus, 25OHvitD, and serum alkaline phosphatase (P>0.05). Total lean mass was greater in GG genotype (P=0.028). Total body less head area (P=0.044), spine BMD (P=0.04), and total femoral BMC (P=0.049) were lower in AG heterozygote genotype. This study show LRP5 polymorphism may associate with body composition and BMD in Iranian children. However, further investigations should be done to evaluate the role of other polymorphism. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 LRP5 nationallicence Bone mineral density nationallicence Body composition nationallicence Ashouri Elham Shiraz Endocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran aut Meimandi Elham Shiraz Institute for Cancer Research (ICR), Shiraz University of Medical Sciences, Shiraz, Iran aut Saki Forough Shiraz Endocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran aut Dabbaghmanesh Mohammad Shiraz Endocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran aut Omrani Gholamhossein Shiraz Endocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran aut Bakhshayeshkaram Marzieh Shiraz Endocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran aut Journal of Bone and Mineral Metabolism Springer Japan 33/6(2015-11-01), 651-657 0914-8779 33:6<651 2015 33 774 https://doi.org/10.1007/s00774-014-0624-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0624-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ashouri Elham Shiraz Endocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran aut NATIONALLICENCE 700 1- Meimandi Elham Shiraz Institute for Cancer Research (ICR), Shiraz University of Medical Sciences, Shiraz, Iran aut NATIONALLICENCE 700 1- Saki Forough Shiraz Endocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran aut NATIONALLICENCE 700 1- Dabbaghmanesh Mohammad Shiraz Endocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran aut NATIONALLICENCE 700 1- Omrani Gholamhossein Shiraz Endocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran aut NATIONALLICENCE 700 1- Bakhshayeshkaram Marzieh Shiraz Endocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/6(2015-11-01), 651-657 0914-8779 33:6<651 2015 33 774