A missense single nucleotide polymorphism, V114I of the Werner syndrome gene, is associated with risk of osteoporosis and femoral fracture in the Japanese population
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| 024 | 7 | 0 | |a 10.1007/s00774-014-0636-0 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00774-014-0636-0 | ||
| 245 | 0 | 2 | |a A missense single nucleotide polymorphism, V114I of the Werner syndrome gene, is associated with risk of osteoporosis and femoral fracture in the Japanese population |h [Elektronische Daten] |c [Heying Zhou, Seijiro Mori, Masashi Tanaka, Motoji Sawabe, Tomio Arai, Masaaki Muramatsu, Makiko Mieno, Shoji Shinkai, Yoshiji Yamada, Motohiko Miyachi, Haruka Murakami, Kiyoshi Sanada, Hideki Ito] |
| 520 | 3 | |a Werner syndrome is a rare autosomal recessive disorder caused by mutations in the human WRN gene and characterized by the early onset of normal aging symptoms. Given that patients with this disease exhibit osteoporosis, the present study aimed to determine whether the WRN gene contributes to the etiology of osteoporosis. A genetic association study of eight non-synonymous polymorphisms in the WRN gene and the incidence of femoral fracture was undertaken in 1,632 consecutive Japanese autopsies in which 140 patients had experienced the fracture during their lifetime. The results were validated in 251 unrelated postmenopausal Japanese women with osteoporosis and 269 non-institutionalized, community-dwelling Japanese adults. A statistically significant association was observed between rs2230009 (c.340G>A)—which results in a Val to Ile substitution—and fracture risk; the incidence of femoral fracture increased dose-dependently with the number of A alleles (p=0.0120). Femoral neck bone and whole bone densities were lower among postmenopausal women with osteoporosis and community-dwelling adults, respectively, if they were of the AG instead of the GG genotype. The results suggest that Japanese subjects bearing at least one A allele of rs2230009 of the WRN gene are at a significantly higher risk of femoral fracture, possibly due to decreased bone density. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2015 | ||
| 690 | 7 | |a Femoral fracture |2 nationallicence | |
| 690 | 7 | |a Osteoporosis |2 nationallicence | |
| 690 | 7 | |a Single nucleotide polymorphism |2 nationallicence | |
| 690 | 7 | |a Werner syndrome |2 nationallicence | |
| 700 | 1 | |a Zhou |D Heying |u Center for Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakae, 173-0015, Itabashi, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Mori |D Seijiro |u Center for Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakae, 173-0015, Itabashi, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Tanaka |D Masashi |u Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Sawabe |D Motoji |u Section of Molecular Pathology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Arai |D Tomio |u Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Muramatsu |D Masaaki |u Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Mieno |D Makiko |u Department of Medical Informatics, Center for Information, Jichi Medical University, Shimotsuke, Tochigi, Japan |4 aut | |
| 700 | 1 | |a Shinkai |D Shoji |u Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Yamada |D Yoshiji |u Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie, Japan |4 aut | |
| 700 | 1 | |a Miyachi |D Motohiko |u Department of Health Promotion and Exercise, National Institute of Health and Nutrition, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Murakami |D Haruka |u Department of Health Promotion and Exercise, National Institute of Health and Nutrition, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Sanada |D Kiyoshi |u Faculty of Sport and Health Science, Ritsumeikan University, Kita, Shiga, Japan |4 aut | |
| 700 | 1 | |a Ito |D Hideki |u President, Local Independent Administrative Agency, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/6(2015-11-01), 694-700 |x 0914-8779 |q 33:6<694 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-014-0636-0 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-014-0636-0 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhou |D Heying |u Center for Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakae, 173-0015, Itabashi, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mori |D Seijiro |u Center for Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakae, 173-0015, Itabashi, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tanaka |D Masashi |u Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sawabe |D Motoji |u Section of Molecular Pathology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Arai |D Tomio |u Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Muramatsu |D Masaaki |u Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mieno |D Makiko |u Department of Medical Informatics, Center for Information, Jichi Medical University, Shimotsuke, Tochigi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shinkai |D Shoji |u Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yamada |D Yoshiji |u Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Miyachi |D Motohiko |u Department of Health Promotion and Exercise, National Institute of Health and Nutrition, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Murakami |D Haruka |u Department of Health Promotion and Exercise, National Institute of Health and Nutrition, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sanada |D Kiyoshi |u Faculty of Sport and Health Science, Ritsumeikan University, Kita, Shiga, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ito |D Hideki |u President, Local Independent Administrative Agency, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/6(2015-11-01), 694-700 |x 0914-8779 |q 33:6<694 |1 2015 |2 33 |o 774 | ||