caa a22 4500 605463077 CHVBK 20210128100251.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00774-014-0629-z doi (NATIONALLICENCE)springer-10.1007/s00774-014-0629-z Sex hormone levels as determinants of bone mineral density and osteoporosis in Vietnamese women and men [Elektronische Daten] [Huong Nguyen, Bo von Schoultz, Tuan Nguyen, Trinh Thang, Tran Chau, Pham Duc, Angelica Hirschberg] This study sought to investigate the prevalence of osteoporosis and the role of sex hormone levels in the determination of bone mineral density (BMD) and osteoporosis in a Vietnamese population of women and men. The cross-sectional study involved 269 women and 222 men aged 13-83years, who were randomly selected from urban and rural areas in northern Vietnam. Serum concentrations of estradiol and testosterone were analyzed, and BMD was measured by dual X-ray absorptiometry. We found that the prevalence of osteoporosis in postmenopausal women was 18, 17, and 37% for the femoral neck, total hip, and lumbar spine, respectively. For men aged 50years or older, the corresponding values were 8, 7, and 12%. In men, the most important predictors of BMD for the femoral neck and total hip were age, body mass index, and serum levels of estradiol. For the BMD of the lumbar spine, testosterone also had a significant influence. Determinants of osteoporosis in men for the total hip and lumbar spine were age, weight, and serum concentrations of estradiol and testosterone. In postmenopausal women, age, weight, and residence (urban vs rural) were the most important predictors of BMD and osteoporosis. For all women (including those of reproductive age), serum levels of estradiol were also significant. These data suggest that the prevalence of osteoporosis in the Vietnamese population is high also in men, and that estradiol levels are essential for bone mass in both men and women. The results should have clinical implications and increase awareness of an important health issue within Vietnamese society. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Bone mineral density nationallicence Osteoporosis nationallicence Estrogen nationallicence Testosterone nationallicence Vietnamese women and men nationallicence Nguyen Huong Department of Women's and Children's Health, Karolinska Institutet and University Hospital, 171-76, Stockholm, Sweden aut von Schoultz Bo Department of Women's and Children's Health, Karolinska Institutet and University Hospital, 171-76, Stockholm, Sweden aut Nguyen Tuan Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, NSW, Sydney, Australia aut Thang Trinh Dinh Tien Hoang Institute of Medicine, Hanoi, Vietnam aut Chau Tran Department of Rheumatology, Bach Mai Hospital, Hanoi, Vietnam aut Duc Pham Department of Physiology, Hanoi Medical University, Hanoi, Vietnam aut Hirschberg Angelica Department of Women's and Children's Health, Karolinska Institutet and University Hospital, 171-76, Stockholm, Sweden aut Journal of Bone and Mineral Metabolism Springer Japan 33/6(2015-11-01), 658-665 0914-8779 33:6<658 2015 33 774 https://doi.org/10.1007/s00774-014-0629-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0629-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nguyen Huong Department of Women's and Children's Health, Karolinska Institutet and University Hospital, 171-76, Stockholm, Sweden aut NATIONALLICENCE 700 1- von Schoultz Bo Department of Women's and Children's Health, Karolinska Institutet and University Hospital, 171-76, Stockholm, Sweden aut NATIONALLICENCE 700 1- Nguyen Tuan Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, NSW, Sydney, Australia aut NATIONALLICENCE 700 1- Thang Trinh Dinh Tien Hoang Institute of Medicine, Hanoi, Vietnam aut NATIONALLICENCE 700 1- Chau Tran Department of Rheumatology, Bach Mai Hospital, Hanoi, Vietnam aut NATIONALLICENCE 700 1- Duc Pham Department of Physiology, Hanoi Medical University, Hanoi, Vietnam aut NATIONALLICENCE 700 1- Hirschberg Angelica Department of Women's and Children's Health, Karolinska Institutet and University Hospital, 171-76, Stockholm, Sweden aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/6(2015-11-01), 658-665 0914-8779 33:6<658 2015 33 774