caa a22 4500 605463085 CHVBK 20210128100251.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00774-014-0626-2 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0626-2 Skeletal deterioration following ovarian failure: can some features be a direct consequence of estrogen loss while others are more related to physical inactivity? [Elektronische Daten] [Hélder Fonseca, Daniel Moreira-Gonçalves, Francisco Amado, José Esteves, José Duarte] Findings on experimental animals show that ovarian failure is a ccompanied by a decrease in motor activity. As mechanical loading has a vital role in the maintenance of skeletal health, our aim was to determine to what extent this decrease in motor activity contributes to ovariectomy-induced bone loss. Thirty-two female Wistar rats were ovariectomized or sham-operated and housed in standard cages or with access to running wheels for 36 weeks with their running distance monitored. Markers of bone turnover were assayed in the serum, and bone geometry, trabecular and cortical bone microarchitecture, mineralization degree, and biomechanical properties were assessed in the femur. Differences between groups were determined by one-way ANOVA. Although reduced motor activity and sex steroid deficiency both resulted in decreases in trabecular bone volume, trabecular number decreases were mostly associated with sex steroid deficiency, whereas trabecular thickness decreases were mostly associated with sedentary behavior. Cortical bone appeared to be more sensitive to variations in motor activity, whereas bone turnover rate and bone tissue mineralization degree seemed to be primarily affected by sex steroid deficiency, even though they were further aggravated by sedentary behavior. Increases in femur length were mostly a consequence of sex steroid deficiency, whereas femoral neck length was also influenced by sedentary behavior. Differences in mechanical properties resulted mostly from differences in physical activity. Both the direct effect of sex steroid deficiency and the indirect effect of motor activity changes are implicated in bone loss following ovariectomy. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Menopause nationallicence Bone quality nationallicence Voluntary motor activity nationallicence Sedentary behavior nationallicence Osteoporosis nationallicence Fonseca Hélder CIAFEL, Faculty of Sport, University of Porto, Rua Dr. Plácido Costa 91, 4200-450, Porto, Portugal aut Moreira-Gonçalves Daniel CIAFEL, Faculty of Sport, University of Porto, Rua Dr. Plácido Costa 91, 4200-450, Porto, Portugal aut Amado Francisco Escola Superior de Saude, Universidade de Aveiro, Aveiro, Portugal aut Esteves José INEGI, Faculty of Engineering, University of Porto, Porto, Portugal aut Duarte José CIAFEL, Faculty of Sport, University of Porto, Rua Dr. Plácido Costa 91, 4200-450, Porto, Portugal aut Journal of Bone and Mineral Metabolism Springer Japan 33/6(2015-11-01), 605-614 0914-8779 33:6<605 2015 33 774 https://doi.org/10.1007/s00774-014-0626-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0626-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fonseca Hélder CIAFEL, Faculty of Sport, University of Porto, Rua Dr. Plácido Costa 91, 4200-450, Porto, Portugal aut NATIONALLICENCE 700 1- Moreira-Gonçalves Daniel CIAFEL, Faculty of Sport, University of Porto, Rua Dr. Plácido Costa 91, 4200-450, Porto, Portugal aut NATIONALLICENCE 700 1- Amado Francisco Escola Superior de Saude, Universidade de Aveiro, Aveiro, Portugal aut NATIONALLICENCE 700 1- Esteves José INEGI, Faculty of Engineering, University of Porto, Porto, Portugal aut NATIONALLICENCE 700 1- Duarte José CIAFEL, Faculty of Sport, University of Porto, Rua Dr. Plácido Costa 91, 4200-450, Porto, Portugal aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/6(2015-11-01), 605-614 0914-8779 33:6<605 2015 33 774