caa a22 4500 605463093 CHVBK 20210128100251.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00774-014-0635-1 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0635-1 Number of osteoporotic sites as a modifying factor for bone mineral density [Elektronische Daten] [Jong Lee, Sungwha Lee, Ohk-Hyun Ryu, Moon-Gi Choi, Youn Kim] Discordance has been proposed as a new predictor of fracture risk that may affect fracture risk via bone mineral density (BMD). With an emphasis on better understanding the relationship between discordance and BMD, the aim of this study was to determine the effect of the number of osteoporotic sites, as an indicator of discordance, on BMD and to explore the clinical significance of BMD modification by this factor. This study was based on data obtained from the Korea National Health and Nutrition Examination Survey 2008-2011, which is a nationwide cross-sectional study. Among postmenopausal women aged 50years or older, 3,849 women whose BMD was measured at three sites (lumbar spine, femoral neck, and total hip) were included in the study. The diagnosis was consistent across sites in only 39.2-59.0% of cases. Lumbar spine T-score was reduced by 0.163 for two osteoporotic sites and by 0.462 for three osteoporotic sites, compared with having one osteoporotic site at the lumbar spine only. Femoral neck T-score was reduced by 0.609 for three osteoporotic sites compared with one or two osteoporotic sites. Using BMD adjusted for discordance, we found fracture risk probability changed significantly. Our results confirmed that BMD discordance was considerably high among Korean women in their 50s and older owing to site-dependent differences in the pattern of BMD reduction with age. Mean BMD decreased with increasing number of osteoporotic sites. Using a modified BMD adjusted for the number of osteoporotic sites may offer more accurate fracture risk assessment. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Bone mineral density nationallicence Discordance nationallicence Fracture risk assessment nationallicence Osteoporosis nationallicence Lee Jong School of Business Administration, Hallym University, Hallimdaehak-gil, 200-702, Chuncheon-si, Gangwon-do, Korea aut Lee Sungwha Department of Internal Medicine, Chuncheon Sacred Hospital, Hallym University College of Medicine, 77 Sakju-ro, 200-704, Chuncheon-si, Gangwon-do, Korea aut Ryu Ohk-Hyun Department of Internal Medicine, Chuncheon Sacred Hospital, Hallym University College of Medicine, 77 Sakju-ro, 200-704, Chuncheon-si, Gangwon-do, Korea aut Choi Moon-Gi Department of Internal Medicine, Chuncheon Sacred Hospital, Hallym University College of Medicine, 77 Sakju-ro, 200-704, Chuncheon-si, Gangwon-do, Korea aut Kim Youn University of Queensland Medical School, Locked Bag 3333, 4670, Bundaberg DC, QLD, Australia aut Journal of Bone and Mineral Metabolism Springer Japan 33/6(2015-11-01), 684-693 0914-8779 33:6<684 2015 33 774 https://doi.org/10.1007/s00774-014-0635-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0635-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Jong School of Business Administration, Hallym University, Hallimdaehak-gil, 200-702, Chuncheon-si, Gangwon-do, Korea aut NATIONALLICENCE 700 1- Lee Sungwha Department of Internal Medicine, Chuncheon Sacred Hospital, Hallym University College of Medicine, 77 Sakju-ro, 200-704, Chuncheon-si, Gangwon-do, Korea aut NATIONALLICENCE 700 1- Ryu Ohk-Hyun Department of Internal Medicine, Chuncheon Sacred Hospital, Hallym University College of Medicine, 77 Sakju-ro, 200-704, Chuncheon-si, Gangwon-do, Korea aut NATIONALLICENCE 700 1- Choi Moon-Gi Department of Internal Medicine, Chuncheon Sacred Hospital, Hallym University College of Medicine, 77 Sakju-ro, 200-704, Chuncheon-si, Gangwon-do, Korea aut NATIONALLICENCE 700 1- Kim Youn University of Queensland Medical School, Locked Bag 3333, 4670, Bundaberg DC, QLD, Australia aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/6(2015-11-01), 684-693 0914-8779 33:6<684 2015 33 774