caa a22 4500 605463107 CHVBK 20210128100251.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00774-014-0631-5 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0631-5 The FRAX® as a predictor of mortality in Japanese incident hemodialysis patients: an observational, follow-up study [Elektronische Daten] [Toshihide Hayashi, Nobuhiko Joki, Yuri Tanaka, Masaki Iwasaki, Shun Kubo, Takasuke Asakawa, Ai Matsukane, Yasunori Takahashi, Yoshihiko Imamura, Koichi Hirahata, Hiroki Hase] The World Health Organization Fracture Risk Assessment Tool (FRAX®) was recently developed to estimate the 10-year absolute risk of osteoporotic fracture among the general population. However, the evidence for its use in chronic kidney disease patients has been lacking, and the association between the FRAX® and mortality is unknown. Therefore, a hospital-based, prospective, cohort study was conducted to evaluate the predictive ability of the FRAX® for mortality in hemodialysis patients. A total of 252 patients who had been started on maintenance hemodialysis, 171 men and 81 women, with a mean age of 67±14years, was studied. The endpoint was defined as all-cause death. The Cox proportional hazards model was used to calculate hazard ratios and 95% confidence intervals. During the mean follow-up period of 3.4±2.7years, 61 deaths occurred. The median (interquartile range) of the FRAX® for major osteoporotic fracture was 6.9 (4.6-12.0) % in men and 19.0 (7.6-33.0) % in women. Cumulative survival rates at 5years after starting dialysis, with the FRAX® levels above and below the median, were 51.9 and 87.9%, respectively, in men and 67.4 and 83.7%, respectively, in women. Overall, in men, the multivariate Cox regression analyses revealed that the log-transformed FRAX® remained an independent predictor of death after adjusting by confounding variables. However, in women, the significant association between the FRAX® value and the outcome was eliminated if age was put into these models. Among Japanese hemodialysis patients, the FRAX® seems to be useful for predicting death, especially in men. The Japanese Society for Bone and Mineral Research and Springer Japan, 2015 CKD nationallicence FRAX nationallicence Hemodialysis nationallicence Mortality nationallicence Hayashi Toshihide Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut Joki Nobuhiko Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut Tanaka Yuri Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut Iwasaki Masaki Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut Kubo Shun Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut Asakawa Takasuke Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut Matsukane Ai Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut Takahashi Yasunori Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut Imamura Yoshihiko Division of Dialysis, Nissan Tamagawa Hospital, Tokyo, Japan aut Hirahata Koichi Hirahata Clinic, Tokyo, Japan aut Hase Hiroki Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut Journal of Bone and Mineral Metabolism Springer Japan 33/6(2015-11-01), 674-683 0914-8779 33:6<674 2015 33 774 https://doi.org/10.1007/s00774-014-0631-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0631-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hayashi Toshihide Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut NATIONALLICENCE 700 1- Joki Nobuhiko Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut NATIONALLICENCE 700 1- Tanaka Yuri Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut NATIONALLICENCE 700 1- Iwasaki Masaki Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut NATIONALLICENCE 700 1- Kubo Shun Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut NATIONALLICENCE 700 1- Asakawa Takasuke Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut NATIONALLICENCE 700 1- Matsukane Ai Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut NATIONALLICENCE 700 1- Takahashi Yasunori Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut NATIONALLICENCE 700 1- Imamura Yoshihiko Division of Dialysis, Nissan Tamagawa Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Hirahata Koichi Hirahata Clinic, Tokyo, Japan aut NATIONALLICENCE 700 1- Hase Hiroki Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, 153-8515, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/6(2015-11-01), 674-683 0914-8779 33:6<674 2015 33 774