caa a22 4500 605463115 CHVBK 20210128100251.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00774-014-0634-2 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0634-2 Higher plasma platelet-activating factor levels are associated with increased risk of vertebral fracture and lower bone mineral density in postmenopausal women [Elektronische Daten] [Hyeonmok Kim, Beom-Jun Kim, Seong Ahn, Seung Lee, Jung-Min Koh] Despite experimental and animal evidence showing the detrimental effects of platelet-activating factor (PAF) on bone metabolism, there are no clinical studies relating PAF to osteoporosis-related phenotypes. This case-control study investigates the association between plasma PAF, osteoporotic vertebral fracture (VF), and bone mineral density (BMD) in postmenopausal Korean women. Among 474 eligible women not taking any drug or having any disease that could affect bone metabolism, we identified 73 cases defined as subjects with radiological VF. The controls were randomly selected from the remaining 401 subjects and matched 1:1 to cases in terms of both age and body mass index (BMI). Lateral thoracolumbar radiographs, BMD, and plasma PAF levels were determined for all subjects. Postmenopausal women with VF demonstrated 34.6% higher plasma PAF levels than subjects without VF after adjusting for age, BMI, smoking habits, alcohol intake, regular exercise, and parental history of osteoporotic fractures (P=0.021). Multiple logistic regression analyses revealed that the odds ratio for VF linearly increased across increasing PAF quartiles (P for trend=0.040) and the odds for VF were 2.88-fold higher in subjects in the highest quartile in comparison with those in the lowest quartile (95% CI 1.04-8.01). Plasma PAF levels were inversely correlated with BMD at various sites (γ=−0.253 to −0.176, P=0.003-0.041). These findings suggest that plasma PAF may be a potential biomarker for predicting poor bone health in postmenopausal women. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Platelet-activating factor nationallicence Vertebral fracture nationallicence Bone mineral density nationallicence Osteoporosis nationallicence Postmenopause nationallicence Kim Hyeonmok Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap2-Dong, Songpa-Gu, 138-736, Seoul, Korea aut Kim Beom-Jun Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap2-Dong, Songpa-Gu, 138-736, Seoul, Korea aut Ahn Seong Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap2-Dong, Songpa-Gu, 138-736, Seoul, Korea aut Lee Seung Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap2-Dong, Songpa-Gu, 138-736, Seoul, Korea aut Koh Jung-Min Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap2-Dong, Songpa-Gu, 138-736, Seoul, Korea aut Journal of Bone and Mineral Metabolism Springer Japan 33/6(2015-11-01), 701-707 0914-8779 33:6<701 2015 33 774 https://doi.org/10.1007/s00774-014-0634-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0634-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Hyeonmok Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap2-Dong, Songpa-Gu, 138-736, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Beom-Jun Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap2-Dong, Songpa-Gu, 138-736, Seoul, Korea aut NATIONALLICENCE 700 1- Ahn Seong Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap2-Dong, Songpa-Gu, 138-736, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Seung Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap2-Dong, Songpa-Gu, 138-736, Seoul, Korea aut NATIONALLICENCE 700 1- Koh Jung-Min Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap2-Dong, Songpa-Gu, 138-736, Seoul, Korea aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/6(2015-11-01), 701-707 0914-8779 33:6<701 2015 33 774