caa a22 4500 605463131 CHVBK 20210128100251.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00774-014-0639-x doi (NATIONALLICENCE)springer-10.1007/s00774-014-0639-x Chronic kidney disease and bone metabolism [Elektronische Daten] [Junichiro Kazama, Koji Matsuo, Yoshiko Iwasaki, Masafumi Fukagawa] Chronic kidney disease-related mineral and bone disease (CKD-MBD) is a syndrome defined as a systemic mineral metabolic disorder associated with CKD, and the term renal osteodystrophy indicates a pathomorphological concept of bone lesions associated with CKD-MBD. Cortical bone thinning, abnormalities in bone turnover and primary/secondary mineralization, elevated levels of circulating sclerostin, increased apoptosis in osteoblasts and osteocytes, disturbance of the coupling phenomenon, iatrogenic factors, accumulated micro-crackles, crystal/collagen disorientation, and chemical modification of collagen crosslinks are all possible candidates found in CKD that could promote osteopenia and/or bone fragility. Some of above factors are the consequences of abnormal systemic mineral metabolism but for others it seem unlikely. We have used the term uremic osteoporosis to describe the uremia-induced bone fragility which is not derived from abnormal systemic mineral metabolism. Interestingly, the disease aspect of uremic osteoporosis appears to be similar to that of senile osteoporosis. The Japanese Society for Bone and Mineral Research and Springer Japan, 2015 Chronic kidney disease (CKD) nationallicence Chronic kidney disease-related mineral and bone disease (CKD-MBD) nationallicence Uremic osteoporosis nationallicence Material property nationallicence Kazama Junichiro Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan aut Matsuo Koji Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan aut Iwasaki Yoshiko Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita, Japan aut Fukagawa Masafumi Division of Nephrology and Metabolism, Tokai University School of Medicine, Isehara, Japan aut Journal of Bone and Mineral Metabolism Springer Japan 33/3(2015-05-01), 245-252 0914-8779 33:3<245 2015 33 774 https://doi.org/10.1007/s00774-014-0639-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0639-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kazama Junichiro Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan aut NATIONALLICENCE 700 1- Matsuo Koji Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan aut NATIONALLICENCE 700 1- Iwasaki Yoshiko Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita, Japan aut NATIONALLICENCE 700 1- Fukagawa Masafumi Division of Nephrology and Metabolism, Tokai University School of Medicine, Isehara, Japan aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/3(2015-05-01), 245-252 0914-8779 33:3<245 2015 33 774