caa a22 4500 60546314X CHVBK 20210128100252.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00774-014-0590-x doi (NATIONALLICENCE)springer-10.1007/s00774-014-0590-x Longitudinal assessment of bone quality in pediatric patients with chronic kidney disease in relation to treatment modality [Elektronische Daten] [Chrysa Gkogka, Athanasios Christoforidis, Nikoleta Printza, Konstantinos Kollios, Eirini Kazantzidou, Fotios Papachristou] Children with chronic kidney disease (CKD) are at high risk of developing impaired bone quality. Our aim was to investigate changes of bone quality in children with CKD in relation to their treatmant using two imaging techniques—dual energy X-ray absorptiometry and quantitative ultraSonography (QUS). Thirty-three patients with CKD (18 boys and 15 girls, mean age 10.37±3.37years) were evaluated with bone mineral density (BMD) measured by DXA at the lumbar spine and hip and with speed of sound (SOS) measured by QUS at the radius and tibia at the beginning and at the end of the study. The patient cohort consisted of 14 patients with CKD stage 3-4 not treated with dialysis (CKD group), 5 patients on peritoneal dialysis treatment (PD group) and 14 patients after kidney transplantation (RTx group). BMD measurements did not show any significant changes in CKD and PD patients during the study. There was a reduction in BMD measured at the lumbar spine, femoral neck and total hip in RTx patients that was approaching significance. During the 2-year follow-up, SOS measurements at the radius decreased significantly in PD patients, whereas SOS measurements at the tibia significantly improved in RTx patients. No significant changes in QUS parameters were recorded for patients in the CKD group. In conclusion, our study shows that QUS parameters seem to better reflect the state of hyperparathyroidism of renal osteodystrophy as they deteriorate significantly in patients on dialysis and improve after renal transplantation. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 CKD nationallicence Children nationallicence Bone nationallicence DXA nationallicence QUS nationallicence Gkogka Chrysa 1st Paediatric Department, Aristotle University, 49, Konstantinoupoleos str, 54642, Thessaloniki, Greece aut Christoforidis Athanasios 1st Paediatric Department, Aristotle University, 49, Konstantinoupoleos str, 54642, Thessaloniki, Greece aut Printza Nikoleta 1st Paediatric Department, Aristotle University, 49, Konstantinoupoleos str, 54642, Thessaloniki, Greece aut Kollios Konstantinos 3rd Paediatric Department, Aristotle University, Thessaloniki, Greece aut Kazantzidou Eirini Radiology Department, Ippokratio General Hospital, Thessaloniki, Greece aut Papachristou Fotios 1st Paediatric Department, Aristotle University, 49, Konstantinoupoleos str, 54642, Thessaloniki, Greece aut Journal of Bone and Mineral Metabolism Springer Japan 33/3(2015-05-01), 303-310 0914-8779 33:3<303 2015 33 774 https://doi.org/10.1007/s00774-014-0590-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0590-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gkogka Chrysa 1st Paediatric Department, Aristotle University, 49, Konstantinoupoleos str, 54642, Thessaloniki, Greece aut NATIONALLICENCE 700 1- Christoforidis Athanasios 1st Paediatric Department, Aristotle University, 49, Konstantinoupoleos str, 54642, Thessaloniki, Greece aut NATIONALLICENCE 700 1- Printza Nikoleta 1st Paediatric Department, Aristotle University, 49, Konstantinoupoleos str, 54642, Thessaloniki, Greece aut NATIONALLICENCE 700 1- Kollios Konstantinos 3rd Paediatric Department, Aristotle University, Thessaloniki, Greece aut NATIONALLICENCE 700 1- Kazantzidou Eirini Radiology Department, Ippokratio General Hospital, Thessaloniki, Greece aut NATIONALLICENCE 700 1- Papachristou Fotios 1st Paediatric Department, Aristotle University, 49, Konstantinoupoleos str, 54642, Thessaloniki, Greece aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/3(2015-05-01), 303-310 0914-8779 33:3<303 2015 33 774