Atypical femoral fracture in a patient treated with denosumab

Verfasser / Beitragende:
[Kareeann Khow, Tuck Yong]
Ort, Verlag, Jahr:
2015
Enthalten in:
Journal of Bone and Mineral Metabolism, 33/3(2015-05-01), 355-358
Format:
Artikel (online)
ID: 605463158
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024 7 0 |a 10.1007/s00774-014-0606-6  |2 doi 
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245 0 0 |a Atypical femoral fracture in a patient treated with denosumab  |h [Elektronische Daten]  |c [Kareeann Khow, Tuck Yong] 
520 3 |a Atypical fractures of the femur (AFF) have been reported in the literature at an increasing rate over the past decade, especially in patients who have been on prolonged courses of bisphosphonates. However, there have only been a few reported cases of AFF in those treated with other antiresorptive medications. In this case report, a 72-year-old woman with chronic obstructive pulmonary disease and osteoporosis presented with an atraumatic right femoral fracture in the setting of denosumab use. In contrast with other reports, this patient had received bisphosphonate therapy for a short duration before the switch to denosumab. While causality between the fracture and denosumab use cannot be established in this case, there is a growing number of reports of a similar association. Ongoing vigilance is required to determine whether denosumab is associated with or potentially a cause of AFF. 
540 |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 
690 7 |a Atypical femoral fractures  |2 nationallicence 
690 7 |a Denosumab  |2 nationallicence 
690 7 |a Osteoporosis  |2 nationallicence 
700 1 |a Khow  |D Kareeann  |u Department of Aged and Extended Care, The Queen Elizabeth Hospital and University of Adelaide, Adelaide, SA, Australia  |4 aut 
700 1 |a Yong  |D Tuck  |u Flinders Private Hospital, Flinders Drive, Bedford Park, 5042, Adelaide, SA, Australia  |4 aut 
773 0 |t Journal of Bone and Mineral Metabolism  |d Springer Japan  |g 33/3(2015-05-01), 355-358  |x 0914-8779  |q 33:3<355  |1 2015  |2 33  |o 774 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Khow  |D Kareeann  |u Department of Aged and Extended Care, The Queen Elizabeth Hospital and University of Adelaide, Adelaide, SA, Australia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Yong  |D Tuck  |u Flinders Private Hospital, Flinders Drive, Bedford Park, 5042, Adelaide, SA, Australia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Journal of Bone and Mineral Metabolism  |d Springer Japan  |g 33/3(2015-05-01), 355-358  |x 0914-8779  |q 33:3<355  |1 2015  |2 33  |o 774