caa a22 4500 605463166 CHVBK 20210128100252.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00774-014-0588-4 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0588-4 7Tesla MRI of bone microarchitecture discriminates between women without and with fragility fractures who do not differ by bone mineral density [Elektronische Daten] [Gregory Chang, Stephen Honig, Yinxiao Liu, Cheng Chen, Kevin Chu, Chamith Rajapakse, Kenneth Egol, Ding Xia, Punam Saha, Ravinder Regatte] Osteoporosis is a disease of poor bone quality. Bone mineral density (BMD) has limited ability to discriminate between subjects without and with poor bone quality, and assessment of bone microarchitecture may have added value in this regard. Our goals were to use 7T MRI to: (1) quantify and compare distal femur bone microarchitecture in women without and with poor bone quality (defined clinically by presence of fragility fractures); and (2) determine whether microarchitectural parameters could be used to discriminate between these two groups. This study had institutional review board approval, and we obtained written informed consent from all subjects. We used a 28-channel knee coil to image the distal femur of 31 subjects with fragility fractures and 25 controls without fracture on a 7T MRI scanner using a 3-D fast low angle shot sequence (0.234mm×0.234mm×1mm, parallel imaging factor=2, acquisition time=7min 9s). We applied digital topological analysis to quantify parameters of bone microarchitecture. All subjects also underwent standard clinical BMD assessment in the hip and spine. Compared to controls, fracture cases demonstrated lower bone volume fraction and markers of trabecular number, plate-like structure, and plate-to-rod ratio, and higher markers of trabecular isolation, rod disruption, and network resorption (p<0.05 for all). There were no differences in hip or spine BMD T-scores between groups (p>0.05). In receiver-operating-characteristics analyses, microarchitectural parameters could discriminate cases and controls (AUC=0.66-0.73, p<0.05). Hip and spine BMD T-scores could not discriminate cases and controls (AUC=0.58-0.64, p≥0.08). We conclude that 7T MRI can detect bone microarchitectural deterioration in women with fragility fractures who do not differ by BMD. Microarchitectural parameters might some day be used as an additional tool to detect patients with poor bone quality who cannot be detected by dual-energy X-ray absorptiometry (DXA). The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 7Tesla nationallicence Magnetic resonance imaging (MRI) nationallicence Femur nationallicence Osteoporosis nationallicence Microarchitecture nationallicence Chang Gregory Department of Radiology, NYU Langone Medical Center, Center for Musculoskeletal Care, 333 E. 38th Street, 6th Floor, Room 6-210, 10016, New York, NY, USA aut Honig Stephen Osteoporosis Center, Hospital for Joint Diseases, NYU Langone Medical Center, 301 E. 17th Street, Suite 1101, 10003, New York, NY, USA aut Liu Yinxiao Departments of Radiology and Electrical and Computer Engineering, University of Iowa, 3414 Seamans Center for the Engineering Arts and Sciences, 52242, Iowa City, IA, USA aut Chen Cheng Departments of Radiology and Electrical and Computer Engineering, University of Iowa, 3414 Seamans Center for the Engineering Arts and Sciences, 52242, Iowa City, IA, USA aut Chu Kevin Department of Radiology, NYU Langone Medical Center, Center for Biomedical Imaging, 660 First Avenue, 4th Floor, 10016, New York, NY, USA aut Rajapakse Chamith Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, 19104, Philadelphia, PA, USA aut Egol Kenneth Department of Orthopaedic Surgery, Hospital for Joint Diseases, NYU Langone Medical Center, 301 E. 17th Street, 10003, New York, NY, USA aut Xia Ding Department of Radiology, NYU Langone Medical Center, Center for Biomedical Imaging, 660 First Avenue, 4th Floor, 10016, New York, NY, USA aut Saha Punam Departments of Radiology and Electrical and Computer Engineering, University of Iowa, 3414 Seamans Center for the Engineering Arts and Sciences, 52242, Iowa City, IA, USA aut Regatte Ravinder Department of Radiology, NYU Langone Medical Center, Center for Biomedical Imaging, 660 First Avenue, 4th Floor, 10016, New York, NY, USA aut Journal of Bone and Mineral Metabolism Springer Japan 33/3(2015-05-01), 285-293 0914-8779 33:3<285 2015 33 774 https://doi.org/10.1007/s00774-014-0588-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0588-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chang Gregory Department of Radiology, NYU Langone Medical Center, Center for Musculoskeletal Care, 333 E. 38th Street, 6th Floor, Room 6-210, 10016, New York, NY, USA aut NATIONALLICENCE 700 1- Honig Stephen Osteoporosis Center, Hospital for Joint Diseases, NYU Langone Medical Center, 301 E. 17th Street, Suite 1101, 10003, New York, NY, USA aut NATIONALLICENCE 700 1- Liu Yinxiao Departments of Radiology and Electrical and Computer Engineering, University of Iowa, 3414 Seamans Center for the Engineering Arts and Sciences, 52242, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Chen Cheng Departments of Radiology and Electrical and Computer Engineering, University of Iowa, 3414 Seamans Center for the Engineering Arts and Sciences, 52242, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Chu Kevin Department of Radiology, NYU Langone Medical Center, Center for Biomedical Imaging, 660 First Avenue, 4th Floor, 10016, New York, NY, USA aut NATIONALLICENCE 700 1- Rajapakse Chamith Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, 19104, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Egol Kenneth Department of Orthopaedic Surgery, Hospital for Joint Diseases, NYU Langone Medical Center, 301 E. 17th Street, 10003, New York, NY, USA aut NATIONALLICENCE 700 1- Xia Ding Department of Radiology, NYU Langone Medical Center, Center for Biomedical Imaging, 660 First Avenue, 4th Floor, 10016, New York, NY, USA aut NATIONALLICENCE 700 1- Saha Punam Departments of Radiology and Electrical and Computer Engineering, University of Iowa, 3414 Seamans Center for the Engineering Arts and Sciences, 52242, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Regatte Ravinder Department of Radiology, NYU Langone Medical Center, Center for Biomedical Imaging, 660 First Avenue, 4th Floor, 10016, New York, NY, USA aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/3(2015-05-01), 285-293 0914-8779 33:3<285 2015 33 774