caa a22 4500 605463212 CHVBK 20210128100252.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00774-014-0589-3 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0589-3 Multivitamin and mineral supplementation is associated with the reduction of fracture risk and hospitalization rate in Chinese adult males: a randomized controlled study [Elektronische Daten] [Shao-Ming Wang, Liang-Yu Yin, Yu Zhang, Jin-Hu Fan, Irene Chang, Sanford Dawsey, Philip Taylor, Christian Abnet, You-Lin Qiao] Controversy exists in the literature regarding the efficacy of bone health-related nutrients, especially calcium and vitamin D, in preventing fractures. The aim of our present study was to determine the effect of multivitamin and mineral supplementation on fracture incidence among 3,318 participants from a nutritional intervention trial in Linxian, China. A total of 1,461 men and 1,857 women were enrolled and randomized to daily supplementation with 26 vitamins and minerals tablet or placebo pills for 6years, followed by a 16-year post-interventional follow-up. The dates, sites, and causes of the fractures were collected retrospectively via a standardized questionnaire. Cox proportional hazard model was used to estimate hazard ratios and 95% confidence intervals of fracture incidence in the intervention versus the placebo group. A total of 221 fractures (57 in men and 164 in women) occurred during the entire study period of 21 years and 9 months. In men, the supplement reduced the risk of fracture by 63% during the trial period, and this protective effect was sustained and statistically significant when analysis included both the trial period and 5- or 10-year post-intervention follow-up (years 0-11, P=0.04; years 0-16, P=0.02, respectively). The protection against fracture was not apparent >10years after cessation of the intervention. In women, no significant effect of supplementation on fracture incidence was seen in any of the study periods. These results demonstrate that a 6-year multivitamin and mineral intervention was associated with significant reduction of fracture risk and fracture-related hospitalization in men, but not in women. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Multivitamin supplementation nationallicence Fracture risk nationallicence Hospitalization rate nationallicence Nutritional intervention trial nationallicence Wang Shao-Ming Department of Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, 17# South Panjiayuan Lane, Chaoyang District, 100021, Beijing, People's Republic of China aut Yin Liang-Yu Department of Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, 17# South Panjiayuan Lane, Chaoyang District, 100021, Beijing, People's Republic of China aut Zhang Yu Department of Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, 17# South Panjiayuan Lane, Chaoyang District, 100021, Beijing, People's Republic of China aut Fan Jin-Hu Department of Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, 17# South Panjiayuan Lane, Chaoyang District, 100021, Beijing, People's Republic of China aut Chang Irene Miller School of Medicine, University of Miami, 1150 Northwest 14th Street, 33136, Miami, FL, USA aut Dawsey Sanford Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7242, 20892-7335, Bethesda, MD, USA aut Taylor Philip Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7242, 20892-7335, Bethesda, MD, USA aut Abnet Christian Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7242, 20892-7335, Bethesda, MD, USA aut Qiao You-Lin Department of Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, 17# South Panjiayuan Lane, Chaoyang District, 100021, Beijing, People's Republic of China aut Journal of Bone and Mineral Metabolism Springer Japan 33/3(2015-05-01), 294-302 0914-8779 33:3<294 2015 33 774 https://doi.org/10.1007/s00774-014-0589-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0589-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Shao-Ming Department of Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, 17# South Panjiayuan Lane, Chaoyang District, 100021, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Yin Liang-Yu Department of Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, 17# South Panjiayuan Lane, Chaoyang District, 100021, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Yu Department of Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, 17# South Panjiayuan Lane, Chaoyang District, 100021, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Fan Jin-Hu Department of Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, 17# South Panjiayuan Lane, Chaoyang District, 100021, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Chang Irene Miller School of Medicine, University of Miami, 1150 Northwest 14th Street, 33136, Miami, FL, USA aut NATIONALLICENCE 700 1- Dawsey Sanford Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7242, 20892-7335, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Taylor Philip Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7242, 20892-7335, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Abnet Christian Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7242, 20892-7335, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Qiao You-Lin Department of Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, 17# South Panjiayuan Lane, Chaoyang District, 100021, Beijing, People's Republic of China aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/3(2015-05-01), 294-302 0914-8779 33:3<294 2015 33 774