caa a22 4500 605463239 CHVBK 20210128100252.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00774-014-0592-8 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0592-8 25-Hydroxyvitamin D level does not reflect intestinal calcium absorption: an assay using strontium as a surrogate marker [Elektronische Daten] [Marília Camargo, Tatiane Vilaça, Lilian Hayashi, Olguita Rocha, Marise Lazaretti-Castro] There is conflicting evidence as to the optimal serum 25-hydroxyvitamin D [25(OH)D] concentration for intestinal calcium absorption (Abs-Ca). Our purpose was to assess the relationship between vitamin D status and Abs-Ca in postmenopausal women. Fifty volunteers with low bone mass were grouped according to their serum 25(OH)D concentration as follows: mild deficient, <50 nmol/L (DEF) and sufficient, ≥75 nmol/L (SUF). The subjects were submitted to an oral strontium overload test to assess their Abs-Ca. Fasting blood samples were obtained to perform the relevant hormonal and biochemical tests. After the subjects received the test solution, blood samples were drawn at 30, 60, 120, and 240min to determine the strontium concentrations. Abs-Ca was indirectly expressed as the area under the serum strontium concentration curve (AUC). A repeated measures ANOVA was performed to determine the differences among the groups. Pearson's correlation and multiple linear regression analysis were used to study the associations between the variables. The mean 25(OH)D and 1,25-dihydroxyvitamin D [1,25(OH)2D] concentrations differed between the groups (SUF vs. DEF) as follows: 98.7±18.2 vs. 38.4±8.5 nmol/L (p<0.001) and 36.2±10.2 vs. 24.9±4.6 pg/mL (p<0.001), respectively. There was no statistically significant difference between the groups for parathyroid hormone and AUC. Only 1,25(OH)2D influenced the strontium absorption in the last 2h of the test. In the studied population, no correlation between levels of 25(OH)D and Abs-Ca was found. Only 1,25(OH)2D influenced Abs-Ca as measured by a strontium absorption test. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Vitamin D nationallicence Calcium nationallicence Strontium nationallicence Intestinal absorption nationallicence Camargo Marília Division of Endocrinology, School of Medicine, Federal University of São Paulo/UNIFESP, Avenida Nove de Julho, 5581, Apto. 30, Jardim Paulista, CEP 01407-200, São Paulo, SP, Brazil aut Vilaça Tatiane Division of Endocrinology, School of Medicine, Federal University of São Paulo/UNIFESP, Avenida Nove de Julho, 5581, Apto. 30, Jardim Paulista, CEP 01407-200, São Paulo, SP, Brazil aut Hayashi Lilian Division of Endocrinology, School of Medicine, Federal University of São Paulo/UNIFESP, Avenida Nove de Julho, 5581, Apto. 30, Jardim Paulista, CEP 01407-200, São Paulo, SP, Brazil aut Rocha Olguita Section of Clinical Analysis, Technological Center of Minas Gerais (CETEC), Avenida José Cândido da Silveira, Horto Florestal, CEP 31035-536, Belo Horizonte, MG, Brazil aut Lazaretti-Castro Marise Division of Endocrinology, School of Medicine, Federal University of São Paulo/UNIFESP, Avenida Nove de Julho, 5581, Apto. 30, Jardim Paulista, CEP 01407-200, São Paulo, SP, Brazil aut Journal of Bone and Mineral Metabolism Springer Japan 33/3(2015-05-01), 319-328 0914-8779 33:3<319 2015 33 774 https://doi.org/10.1007/s00774-014-0592-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0592-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Camargo Marília Division of Endocrinology, School of Medicine, Federal University of São Paulo/UNIFESP, Avenida Nove de Julho, 5581, Apto. 30, Jardim Paulista, CEP 01407-200, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Vilaça Tatiane Division of Endocrinology, School of Medicine, Federal University of São Paulo/UNIFESP, Avenida Nove de Julho, 5581, Apto. 30, Jardim Paulista, CEP 01407-200, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Hayashi Lilian Division of Endocrinology, School of Medicine, Federal University of São Paulo/UNIFESP, Avenida Nove de Julho, 5581, Apto. 30, Jardim Paulista, CEP 01407-200, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Rocha Olguita Section of Clinical Analysis, Technological Center of Minas Gerais (CETEC), Avenida José Cândido da Silveira, Horto Florestal, CEP 31035-536, Belo Horizonte, MG, Brazil aut NATIONALLICENCE 700 1- Lazaretti-Castro Marise Division of Endocrinology, School of Medicine, Federal University of São Paulo/UNIFESP, Avenida Nove de Julho, 5581, Apto. 30, Jardim Paulista, CEP 01407-200, São Paulo, SP, Brazil aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/3(2015-05-01), 319-328 0914-8779 33:3<319 2015 33 774