Osteocalcin, but not deoxypyridinoline, increases in response to isoflurane-induced anaesthesia in young female guinea pigs
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| 024 | 7 | 0 | |a 10.1007/s00774-014-0593-7 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00774-014-0593-7 | ||
| 245 | 0 | 0 | |a Osteocalcin, but not deoxypyridinoline, increases in response to isoflurane-induced anaesthesia in young female guinea pigs |h [Elektronische Daten] |c [Negar Tabatabaei, Celia Rodd, Richard Kremer, Hope Weiler] |
| 520 | 3 | |a The effect of the inhaled anaesthetic isoflurane was investigated on bone biomarkers, both during maturation and on minerals and glucose postpartum. Female guinea pigs (n=10) were anaesthetized during maturation (5 and 9weeks) and postpartum (26weeks of age) with isoflurane during dual-energy X-ray absorptiometry scanning. Blood collection was performed at all ages before and after anaesthesia for measurement of plasma osteocalcin (OC), total deoxypyridinoline (tDPD), and cortisol. Postpartum measurements also included: blood ions, acid-base parameters and glucose, plasma minerals, total alkaline phosphatase (tALP), and albumin. Plasma OC concentration almost doubled after exposure to isoflurane at 5weeks (30.1±5.0-57.9±11.2nmol/L, p<0.001) and at 9weeks (29.1±7.5-62.9±15.9nmol/L, p<0.001), but did not change postpartum (3.7±3.3-4.3±3.9nmol/L, p=0.88). There was no effect of isoflurane exposure on plasma tDPD at any age. Plasma cortisol increased after exposure to isoflurane at 9weeks (1859.6±383.2-2748.0±235.3nmol/L, p<0.01) and postpartum (3376.7±322.2-4091.6±195.6nmol/L, p<0.001) but not at 5weeks (2088.3±326.4-2464.1±538.0nmol/L, p>0.05). Blood ionized Ca2+, Na+ and plasma total Ca did not change, whereas plasma albumin decreased, and inorganic phosphate (PO4) and Cl− increased upon exposure to isoflurane. Isoflurane decreased tALP (43.2±6.6-40.2±5.9IU/L, p=0.01) and increased glucose (7.5±0.6-10.9±1.7mmol/L, p<0.0001) postpartum. Isoflurane inflates the assessment of a bone-derived biomarker, OC, during rapid growth, but not following pregnancy when formation is very low. Measurements prior to anaesthesia are recommended to reflect normal metabolism. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 | ||
| 690 | 7 | |a Isoflurane |2 nationallicence | |
| 690 | 7 | |a Osteocalcin |2 nationallicence | |
| 690 | 7 | |a Deoxypyridinoline |2 nationallicence | |
| 690 | 7 | |a Guinea pig |2 nationallicence | |
| 700 | 1 | |a Tabatabaei |D Negar |u School of Dietetics and Human Nutrition, Macdonald-Stewart Building Macdonald Campus, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, H9X 3V9, Quebec, Canada |4 aut | |
| 700 | 1 | |a Rodd |D Celia |u Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, 2300 Tupper St., H3H 1P3, Montreal, QC, Canada |4 aut | |
| 700 | 1 | |a Kremer |D Richard |u Department of Medicine, Royal Victoria Hospital, McGill University Health Center, 687 Pine Avenue West, H3A 1A1, Montreal, QC, Canada |4 aut | |
| 700 | 1 | |a Weiler |D Hope |u School of Dietetics and Human Nutrition, Macdonald-Stewart Building Macdonald Campus, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, H9X 3V9, Quebec, Canada |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/3(2015-05-01), 253-260 |x 0914-8779 |q 33:3<253 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-014-0593-7 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-014-0593-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tabatabaei |D Negar |u School of Dietetics and Human Nutrition, Macdonald-Stewart Building Macdonald Campus, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, H9X 3V9, Quebec, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rodd |D Celia |u Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, 2300 Tupper St., H3H 1P3, Montreal, QC, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kremer |D Richard |u Department of Medicine, Royal Victoria Hospital, McGill University Health Center, 687 Pine Avenue West, H3A 1A1, Montreal, QC, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Weiler |D Hope |u School of Dietetics and Human Nutrition, Macdonald-Stewart Building Macdonald Campus, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, H9X 3V9, Quebec, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/3(2015-05-01), 253-260 |x 0914-8779 |q 33:3<253 |1 2015 |2 33 |o 774 | ||