caa a22 4500 605463263 CHVBK 20210128100252.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00774-014-0596-4 doi (NATIONALLICENCE)springer-10.1007/s00774-014-0596-4 The protective effect of lycopene intake on bone loss in ovariectomized rats [Elektronische Daten] [Yuki Iimura, Umon Agata, Satoko Takeda, Yuki Kobayashi, Shigeki Yoshida, Ikuko Ezawa, Naomi Omi] Antioxidant lycopene supplementation has been shown to decrease oxidative stress and have beneficial effects on bone health. However, it remains unclear whether lycopene exerts its beneficial effect on bone metabolism through mitigation of oxidative stress in vivo. The aim of this study was to investigate whether lycopene intake protects against bone loss by reducing oxidative stress in ovariectomized rats. Female Sprague-Dawley 6-week-old rats were ovariectomized and randomly divided into four groups according to the lycopene content of their diet: 0, 50, 100, and 200ppm. The tibial bone mineral density (BMD) in the 50, 100, and 200ppm groups was significantly higher than that in the 0ppm group. Serum and urinary bone resorption marker levels were significantly lower in the 50, 100, and 200ppm groups than in the 0ppm group. There was no significant difference in systemic oxidative stress markers among all groups. However, systemic oxidative stress levels were inversely correlated with the tibial BMD. Our findings suggest that lycopene intake significantly inhibits bone loss by suppressing bone resorption in ovariectomized rats. Further studies are necessary to clarify the effect of lycopene on oxidative stress in local tissues such as bone tissue. The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 Bone loss nationallicence Bone resorption nationallicence Lycopene nationallicence Oxidative stress nationallicence Ovariectomized rats nationallicence Iimura Yuki Department of Health and Sport Science, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, 305-8574, Tsukuba, Ibaraki, Japan aut Agata Umon Department of Health and Sport Science, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, 305-8574, Tsukuba, Ibaraki, Japan aut Takeda Satoko Department of Health and Sport Science, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, 305-8574, Tsukuba, Ibaraki, Japan aut Kobayashi Yuki Department of Health and Sport Science, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, 305-8574, Tsukuba, Ibaraki, Japan aut Yoshida Shigeki Department of Life Science and Bioengineering, Graduate School of Life and Environmental Science, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut Ezawa Ikuko Department of Food and Nutrition, School of Home-Economics, Japan Women's University, 2-8-1 Mejirodai, Bunkyo-ku, 112-8681, Tokyo, Japan aut Omi Naomi Department of Health and Sport Science, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, 305-8574, Tsukuba, Ibaraki, Japan aut Journal of Bone and Mineral Metabolism Springer Japan 33/3(2015-05-01), 270-278 0914-8779 33:3<270 2015 33 774 https://doi.org/10.1007/s00774-014-0596-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00774-014-0596-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Iimura Yuki Department of Health and Sport Science, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, 305-8574, Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 700 1- Agata Umon Department of Health and Sport Science, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, 305-8574, Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 700 1- Takeda Satoko Department of Health and Sport Science, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, 305-8574, Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 700 1- Kobayashi Yuki Department of Health and Sport Science, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, 305-8574, Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 700 1- Yoshida Shigeki Department of Life Science and Bioengineering, Graduate School of Life and Environmental Science, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 700 1- Ezawa Ikuko Department of Food and Nutrition, School of Home-Economics, Japan Women's University, 2-8-1 Mejirodai, Bunkyo-ku, 112-8681, Tokyo, Japan aut NATIONALLICENCE 700 1- Omi Naomi Department of Health and Sport Science, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, 305-8574, Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer Japan 33/3(2015-05-01), 270-278 0914-8779 33:3<270 2015 33 774